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Updated: Jun 16, 2025
11:08
A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
Published on: December 9, 2017
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Lysine Acetyltransferase 8: A Target for Natural Compounds in Cancer Therapy.
Lei Wang1, Liting Zhao1, Xintian Lan1
1School of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.
International Journal of Molecular Sciences
|June 13, 2025
Summary
Lysine acetyltransferase 8 (KAT8) plays a key role in cancer by modifying proteins. This review explores how KAT8 impacts tumor growth and discusses agents that target it for cancer therapy.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Lysine acetyltransferase 8 (KAT8) is a MYST family histone acetyltransferase.
- KAT8 catalyzes acetylation of histone H4 at lysine 16 (H4K16ac) and non-histone proteins.
- Altered KAT8 and H4K16ac levels are linked to various malignant tumors, indicating roles in tumorigenesis and progression.
Purpose of the Study:
- To review the molecular mechanisms of KAT8 in tumor development.
- To summarize the impact of KAT8-mediated acetylation on cancer processes.
- To discuss small-molecule agents targeting KAT8 for antitumor activity.
Main Methods:
- Literature review of studies on KAT8 function in cancer.
- Analysis of KAT8's role in regulating protein acetylation.
- Systematic discussion of natural compounds, synthetic drugs, and non-coding RNAs targeting KAT8.
Main Results:
- KAT8 regulates tumor cell proliferation, cell cycle, apoptosis, DNA repair, and autophagy through substrate acetylation.
- Abnormal KAT8 expression is associated with cancer development and progression.
- Various agents, including natural products and synthetic drugs, show potential in targeting KAT8.
Conclusions:
- KAT8 is a critical regulator in tumorigenesis, impacting multiple cellular pathways.
- Targeting KAT8 with small-molecule agents presents a promising therapeutic strategy for cancer treatment.
- Further research into KAT8 inhibitors could lead to novel anticancer therapies.
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