Jove
Visualize
Contact Us
  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Medicinal And Biomolecular Chemistry
  9. Biologically Active Molecules
  11. Unveiling Cytotoxic Bioactive Compounds From Erica Carnea L.: Extraction Optimization, Kinetic Modeling, And Biological Activity Assessment.
  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Medicinal And Biomolecular Chemistry
  9. Biologically Active Molecules
  11. Unveiling Cytotoxic Bioactive Compounds From Erica Carnea L.: Extraction Optimization, Kinetic Modeling, And Biological Activity Assessment.

Related Experiment Video

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

6.3K

Unveiling Cytotoxic Bioactive Compounds from Erica carnea L.: Extraction Optimization, Kinetic Modeling, and Biological Activity Assessment.

Violeta Jevtovic1, Khulood Fahad Saud Alabbosh2, Reem Ali Alyami1

  • 1Chemistry Department, College of Science, University of Ha'il, Ha'il 81451, Saudi Arabia.

Plants (Basel, Switzerland)
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Erica carnea L. extracts show potent cytotoxic, antioxidant, and antibacterial activities. Optimal extraction conditions yielded bioactive compounds with significant therapeutic potential.

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Chemical Engineering

Background:

  • Erica carnea L. is a plant with potential medicinal properties.
  • Bioactive compounds (BCs) from natural sources are increasingly investigated for therapeutic applications.
  • Understanding extraction parameters is crucial for maximizing the yield and activity of BCs.

Purpose of the Study:

  • To investigate the effects of temperature, time, and solvent concentration on the yield and cytotoxic activity of BCs from Erica carnea L.
  • To determine the kinetic and thermodynamic parameters of the extraction process.
  • To evaluate the antioxidant and antibacterial activities of the extracts.

Main Methods:

  • Extraction optimization using varying ethanol concentrations, temperatures, and times.
Keywords:
Ponomarev modelantimicrobial activityantioxidant activitycytotoxic activitynatural sourcethermodynamic parametersunsteady-state diffusion model

More Related Videos

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

9.8K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.1K

Related Experiment Videos

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
08:20

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

6.3K
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

9.8K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

19.1K

Related Concept Videos

JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  • Cytotoxicity assays against Hep2c, RD, and L2OB cell lines.
  • Kinetic modeling (unsteady-state diffusion vs. Ponomarev model).
  • Determination of activation energy and thermodynamic parameters (enthalpy, entropy, free energy).
  • Antioxidant assays (e.g., DPPH) and antibacterial activity tests against multiple bacterial strains.

    • Main Results:

    • Optimal extraction achieved with 30% ethanol, 50 °C, and 80 min, yielding highest cytotoxic activity (IC50 values: 14.29-22.23 µg/mL).
    • Unsteady-state diffusion model best described extraction kinetics.
    • Activation energy ranged from 4.92-26.57 kJ/mol.
    • Thermodynamic parameters indicated an irreversible and endothermic extraction process.
    • Extracts exhibited significant antioxidant (DPPH IC50 = 16.55 µg/mL) and broad-spectrum antibacterial activities.

    Conclusions:

    • Erica carnea L. is a valuable source of multifunctional bioactive compounds.
    • Optimized extraction enhances the yield of compounds with potent cytotoxic, antioxidant, and antibacterial properties.
    • These findings support the therapeutic potential of Erica carnea L. extracts.