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Local Anesthetics: Common Agents and Their Applications01:23

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Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
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  11. The Use Of Cyanoacrylate And Glubran In Dentistry: A Review Of Clinical Applications And Outcomes

The Use of Cyanoacrylate and Glubran in Dentistry: A Review of Clinical Applications and Outcomes

Michele Miranda1, Francesco Gianfreda1, Graziana Molica1

  • 1Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

Materials (Basel, Switzerland)
|June 13, 2025

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Application of Light-cured Dental Adhesive Resin for Mounting Electrodes or Microdialysis Probes in Chronic Experiments
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View abstract on PubMed

Summary
This summary is machine-generated.

Cyanoacrylate adhesives offer faster, less painful dental wound closure than sutures. Glubran II shows promise for hemostasis and stability, but more research is needed on formulations.

Area of Science:

  • Dental Materials Science
  • Biomaterials Engineering
  • Surgical Innovation

Background:

  • Cyanoacrylate adhesives are increasingly used in dentistry due to rapid polymerization, biocompatibility, and antimicrobial properties.
  • Traditional sutures present limitations in operative time, pain, and infection risk for dental procedures.

Purpose of the Study:

  • To review the clinical applications of cyanoacrylate adhesives in dentistry, focusing on wound closure, tissue management, and hemostasis.
  • To evaluate the efficacy and safety of specific formulations, such as Glubran II, compared to conventional methods.

Main Methods:

  • A comprehensive literature search was performed in PubMed, Scopus, and Web of Science databases (2000-2024).
  • Inclusion criteria focused on clinical and in vitro studies of dental cyanoacrylate applications; exclusion criteria targeted non-dental uses and insufficient data.
Keywords:
Glubrancyanoacrilateoral surgeryoral wound

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Main Results:

  • Cyanoacrylates, particularly n-butyl and octyl derivatives, significantly reduce operative time, postoperative pain, and infection rates compared to sutures.
  • Glubran II demonstrates notable efficacy in achieving hemostasis and ensuring wound stability.
  • Variations in degradation rates and cytotoxicity among different cyanoacrylate formulations warrant further investigation.

Conclusions:

  • Cyanoacrylate adhesives represent effective, minimally invasive alternatives for dental surgery.
  • Standardized protocols and long-term comparative studies are essential to fully establish the role of cyanoacrylates in dental practice.