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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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pH-Responsive Hydrogels: Recent Advances in Pharmaceutical Applications.

Georgia Patroklou1, Efstathia Triantafyllopoulou1, Paraskevi-Evelina Goula1

  • 1Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.

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pH-responsive hydrogels offer advanced drug delivery solutions. These smart biomaterials enable controlled release for applications in medicine, wound healing, and beyond.

Keywords:
anticancer therapychitosancontrolled releasedrug deliveryhydrogelspH-responsivepoly(acrylic acid)polymerswound healing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Hydrogels are versatile 3D polymeric networks with high loading capacity and controlled release.
  • Their biocompatibility, biodegradability, and tunable properties make them suitable for biomedical applications.
  • Stimuli-responsive hydrogels, particularly pH-responsive ones, offer triggered drug release capabilities.

Purpose of the Study:

  • To review literature on pH-responsive hydrogels for drug delivery and other biomedical applications.
  • To highlight the role of various polymers and their combinations in hydrogel formulation.
  • To elucidate structure formation, release mechanisms, and therapeutic effects of these hydrogels.

Main Methods:

  • Literature review focusing on pH-responsive hydrogels.
  • Analysis of different polymeric derivatives and their functionalization.
  • Examination of crosslinking methods and content release mechanisms.
  • Evaluation of therapeutic outcomes in various pathological conditions.

Main Results:

  • pH-responsive hydrogels demonstrate significant potential in drug delivery, wound healing, and implantation.
  • Diverse polymeric materials and crosslinking strategies enable tailored hydrogel properties.
  • Controlled release is achieved through pH-induced conformational changes, optimizing therapeutic efficacy.

Conclusions:

  • pH-responsive hydrogels are promising candidates for pharmaceutical applications due to their tunable and stimuli-responsive nature.
  • Further research into polymer selection and structural design can enhance their therapeutic potential.
  • These smart biomaterials offer innovative solutions for targeted drug delivery and regenerative medicine.