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  11. Supercritical Impregnation Of Olive Leaf Extract In Poly(l-lactic Acid-co-caprolactone) Filaments: An Environmentally Friendly Approach To Obtaining Active Biomedical Materials

Supercritical Impregnation of Olive Leaf Extract in Poly(L-lactic acid-co-caprolactone) Filaments: An Environmentally Friendly Approach to Obtaining Active Biomedical Materials

Juan Ramón Montes-Lobato1, Noelia D Machado1, Cristina Cejudo-Bastante1

  • 1Chemical Engineering and Food Technology Department, Faculty of Science, Wine and Agrifood Research Institute (IVAGRO), University of Cadiz, 11510 Puerto Real, Spain.

Polymers
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Olive leaf extract (OLE) rich in bioactives was incorporated into poly(L-lactic-acid-co-caprolactone) (PLCL) filaments using supercritical impregnation. These OLE-active PLCL filaments show sustained release for potential biomedical applications.

Area of Science:

  • Biomaterials Science
  • Green Chemistry
  • Pharmacology

Background:

  • Valorization of olive by-products is crucial for biorefineries.
  • Olive leaves contain bioactive compounds with antioxidant and anti-inflammatory properties.
  • Developing functional biomaterials requires efficient extraction and incorporation methods.

Purpose of the Study:

  • To recover bioactive compounds from olive leaves.
  • To incorporate olive leaf extract (OLE) into poly(L-lactic-acid-co-caprolactone) (PLCL) filaments.
  • To evaluate the potential of OLE-active PLCL filaments for biomedical applications.

Main Methods:

  • Enhanced solvent extraction (ESE) with CO2/ethanol for OLE recovery.
  • Supercritical impregnation technique for incorporating OLE into PLCL filaments.
Keywords:
active compound delivery systemsolive leaf extractpoly(L-lactic-co-caprolactone) (PLCL)supercritical fluid

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  • In vitro release studies and kinetic analysis (Korsmeyer-Peppas model).

    • Main Results:

    • ESE yielded OLE with high antioxidant and anti-inflammatory activity.
    • Supercritical impregnation requires controlled depressurization to prevent PLCL deformation.
    • Impregnation parameters (pressure, temperature) affected OLE loading and filament activity.
    • Prolonged release of active compounds over 90 days was observed.

    Conclusions:

    • Supercritical impregnation is a viable method for creating OLE-active PLCL filaments.
    • These filaments exhibit sustained release of bioactive compounds.
    • OLE-active PLCL filaments hold promise for biomedical applications needing controlled therapeutic delivery.