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Related Concept Videos

Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

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Coagulation Status Assessment in Dogs with Chronic Enteropathy Using Viscoelastic Point-of-Care Coagulation Monitor.

María José Marín Lucas1, Tim Sparks2, Chantal Rosa1

  • 1Northwest Veterinary Specialists, Linnaeus Veterinary Ltd., Delamere House, Ashville Point, Beechwood, Sutton Weaver, Runcorn WA7 3FW, UK.

Animals : an Open Access Journal From MDPI
|June 13, 2025
PubMed
Summary

Canine chronic inflammatory enteropathy (CIE) often leads to a hypercoagulable state, increasing clot risk. A viscoelastic device confirmed hypercoagulability in most dogs with CIE, particularly in immunosuppressive-responsive cases.

Keywords:
VCM Vet®caninecanine chronic enteropathy clinical activity indexchronic inflammatory enteropathyhypercoagulabilityimmunosuppressive therapyprotein-losing enteropathyviscoelastic testing

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Area of Science:

  • Veterinary Medicine
  • Hematology
  • Gastroenterology

Background:

  • Canine chronic inflammatory enteropathy (CIE) is linked to coagulation disorders, potentially causing thromboembolic events.
  • Assessing hypercoagulability in CIE is crucial for understanding disease mechanisms and management.

Purpose of the Study:

  • To evaluate the coagulation status in dogs with CIE using a viscoelastic point-of-care device, the Viscoelastic Coagulation Monitor (VCM Vet®).
  • To identify associations between coagulation status and CIE subtypes.

Main Methods:

  • Retrospective review of medical records for 38 dogs diagnosed with CIE who underwent VCM Vet® testing.
  • Classification of coagulation profiles as hypercoagulable, normocoagulable, or hypocoagulable.

Main Results:

  • 81.5% of dogs with CIE exhibited hypercoagulability.
  • Hypercoagulability was more prevalent in immunosuppressive-responsive enteropathy (IRE) cases.
  • Significant differences in albumin, cobalamin, and the canine chronic enteropathy clinical activity index (CCECAI) were observed across CIE subtypes.

Conclusions:

  • VCM Vet® is an effective tool for assessing coagulation abnormalities in dogs with CIE.
  • Findings support previous reports of hypercoagulability in CIE, especially in IRE.
  • Further research is needed on the clinical impact of hypercoagulability and potential anticoagulant therapies.