Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

2.9K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
2.9K
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview01:27

Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview

1.7K
Wilhelm Rudolph Fittig discovered the pinacol coupling reaction in 1859. It is a radical dimerization reaction and involves the reductive coupling of aldehydes or ketones in the presence of hydrocarbon solvent to yield vicinal diols.
1.7K
Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate02:21

Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate

11.1K
Alkenes can be dihydroxylated using potassium permanganate.  The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.
11.1K
  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Theoretical And Computational Chemistry
  9. Radiation And Matter
  11. Superoxide Scavenging By Capers And Kaempferol, Measured By Hydrodynamic Voltammetry, Shows Kaempferol Synergistic Action With Vitamin C; Density Functional Theory (dft) Results Support Experimental Kaempferol Catalytic Behavior Similar To Superoxide Dismutases (sods).
  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Theoretical And Computational Chemistry
  9. Radiation And Matter
  11. Superoxide Scavenging By Capers And Kaempferol, Measured By Hydrodynamic Voltammetry, Shows Kaempferol Synergistic Action With Vitamin C; Density Functional Theory (dft) Results Support Experimental Kaempferol Catalytic Behavior Similar To Superoxide Dismutases (sods).

Related Experiment Video

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
08:57

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

Published on: February 24, 2018

10.1K

Superoxide Scavenging by Capers and Kaempferol, Measured by Hydrodynamic Voltammetry, Shows Kaempferol Synergistic Action with Vitamin C; Density Functional Theory (DFT) Results Support Experimental Kaempferol Catalytic Behavior Similar to Superoxide Dismutases (SODs).

Miriam Rossi1, Stuart Belli1, Paloma Velez1

  • 1Department of Chemistry, Vassar College, Poughkeepsie, NY 12604, USA.

Molecules (Basel, Switzerland)
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
DFTcaperskaempferolsuperoxide

More Related Videos

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
09:46

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles

Published on: August 26, 2018

8.9K
Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
07:05

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Published on: August 23, 2024

1.5K

Related Experiment Videos

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
08:57

Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases

Published on: February 24, 2018

10.1K
Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles
09:46

Catalytic Scavenging of Plant Reactive Oxygen Species In Vivo by Anionic Cerium Oxide Nanoparticles

Published on: August 26, 2018

8.9K
Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
07:05

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Published on: August 23, 2024

1.5K

Kaempferol, found in capers, acts as a potent antioxidant, outperforming vitamin C. It mimics superoxide dismutase (SOD) enzymes, effectively neutralizing harmful superoxide radicals in a catalytic cycle.

Area of Science:

  • Biochemistry
  • Electrochemistry
  • Computational Chemistry

Background:

  • Superoxide radical anion is a major reactive oxygen species implicated in oxidative stress.
  • Natural products are explored for their antioxidant properties.
  • Understanding antioxidant mechanisms is crucial for developing therapeutic strategies.

Purpose of the Study:

  • To measure the antioxidant capacity of capers and kaempferol against superoxide radicals.
  • To elucidate the scavenging mechanism of kaempferol using electrochemical and computational methods.
  • To investigate the synergistic effect of kaempferol and vitamin C.

Main Methods:

  • Hydrodynamic voltammetry with a rotating ring disk electrode (RRDE) for electrochemical measurements.
  • Density Functional Theory (DFT) for computational modeling of reaction mechanisms.
synergy
voltammetry

Main Results:

  • Kaempferol demonstrated stronger superoxide scavenging activity than vitamin C.
  • Caper extract showed weaker antioxidant capacity than olive oil.
  • A potent synergistic effect was observed between kaempferol and vitamin C, leading to complete superoxide radical scavenging.
  • DFT calculations proposed a catalytic mechanism for kaempferol mimicking superoxide dismutase (SOD) activity.

Conclusions:

  • Kaempferol is a potent antioxidant and a promising SOD mimic.
  • The synergistic action of kaempferol and vitamin C offers a highly effective strategy for superoxide radical neutralization.
  • Capers contain valuable antioxidant compounds with potential health benefits.