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Updated: Jun 16, 2025

Author Spotlight: Plant Primary Organs Profiling Using 13C6-Glucose Labeling and LC-MS
Published on: March 22, 2024
Research Advances in the Synthesis, Metabolism, and Function of Chlorogenic Acid
Yuxin He1, Shengming Mao1, Yingying Zhao1
1Key Laboratory of Quality and Safety Control for Subtropical Fruit and Vegetable, Ministry of Agriculture and Rural Affairs, Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang A&F University, Hangzhou 311300, China.
Abstract:
Chlorogenic acids (CGAs) are a group of important plant secondary metabolites produced in the phenylpropanoid metabolic pathway; they are formed via the conjugation of caffeic and quinic acids and are widely distributed across different plant species. Renowned for their multifunctional activities-including antioxidant, anti-inflammatory, antimicrobial, anticancer, antidiabetic, and anti-obesity properties-CGAs are versatile natural food additives with diverse industrial applications. This review summarizes five distinct CGA biosynthetic pathways, the structural and regulatory genes involved, and their key biological functions. The insights aim to facilitate a deeper understanding of CGA metabolism and streamline its exploitation in agriculture and human health.
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