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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
Published on: February 4, 2018
Three Cases of Lyme Carditis and a Review of Management
Ryan F Coughlin1, Anne Fox2, Erin Underriner3
1Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA.
Insights
Lyme carditis, a complication of Lyme disease, can cause various heart blocks. Prompt diagnosis and treatment with antibiotics like ceftriaxone and doxycycline are crucial for recovery and preventing permanent heart issues.
Area of Science:
- Infectious Diseases
- Cardiology
- Emergency Medicine
Background:
- Lyme carditis, caused by Borrelia burgdorferi, affects 1-10% of untreated Lyme disease patients.
- It can manifest with varying degrees of atrioventricular (AV) block.
- Diagnosis can be challenging due to non-specific symptoms and lack of clear tick exposure history.
Purpose of the Study:
- To review cases of Lyme carditis presenting to an emergency department.
- To highlight the variable presentations of Lyme carditis, including different types of AV block.
- To emphasize the importance of prompt recognition and management in endemic areas.
Main Methods:
- Retrospective review of three emergency department cases of Lyme carditis.
- Analysis of patient demographics, symptoms, cardiac findings (AV block degrees), and treatment outcomes.
- Diagnostic confirmation through Lyme antibody testing and Western blot.
Main Results:
- Three patients presented with first-degree, Type 2 second-degree, and complete heart block.
- All patients received intravenous ceftriaxone, with two also treated with doxycycline.
- All cases showed resolution of AV block following antibiotic treatment, with one requiring temporary pacing.
Conclusions:
- Lyme carditis presents with diverse cardiac manifestations, including significant AV block.
- Early diagnosis and antibiotic treatment (ceftriaxone, doxycycline) are effective in resolving Lyme carditis.
- High clinical suspicion is vital in emergency settings to avoid unnecessary interventions like permanent pacemakers.
Abstract:
Lyme carditis, primarily caused by Borrelia burgdorferi, affects 1 to 10% of patients with untreated Lyme disease. This study reviewed 3 cases of Lyme carditis that presented to a tertiary hospital's emergency department in the northeastern United States during the summer months. The cases involved patients with varying degrees of atrioventricular (AV) block: first-degree, second-degree Type 2, and complete heart block. Case 1 involved a 19-y-old male presenting with syncope and diagnosed with first-degree AV block. He received intravenous (IV) ceftriaxone, resulting in resolution of the AV block. Case 2 was a 22-y-old male who experienced an unresponsive episode with bystander chest compressions. He had discrete erythematous patches and was diagnosed with Type 2 second-degree AV block. IV ceftriaxone followed by doxycycline resolved his condition without further incident. Case 3 described a 32-y-old male with lightheadedness and syncope, diagnosed with complete heart block. A temporary pacing lead and IV ceftriaxone were employed, transitioning to doxycycline, which effectively resolved the heart block. All three patients tested positive for Lyme antibodies with reflex Western blot. Lyme carditis presents variably, often without a clear history of tick exposure or erythema migrans. Prompt recognition and treatment in endemic areas are critical to prevent implantation of unnecessary permanent pacemakers. This paper underscores the importance of high clinical suspicion and reviews appropriate management in the emergency department setting for patients with potential Lyme carditis presenting with unexplained cardiac symptoms.
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