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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

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Updated: Jun 14, 2025

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Murine Models of Obesity-Related Cancer Risk.

Lukmon M Raji1, Monowarul M Siddique2, Margaret S Bohm1

  • 1Department of Microbiology, Immunology and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennesse.

Cancer Prevention Research (Philadelphia, Pa.)
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Obesity significantly increases cancer risk and mortality. This review highlights mouse models used by the Metabolic Dysfunction and Cancer Risk Program (MeDOC) to study obesity-related cancer onset, prevention, and interception.

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Area of Science:

  • Oncology
  • Metabolic Research
  • Translational Science

Background:

  • Obesity affects over 14% of adults globally and over a third of Americans.
  • Obesity is linked to an increased risk of over 13 cancer types and poorer outcomes, including mortality.
  • Current cancer research often focuses on progression rather than risk, necessitating better models for early detection and prevention.

Purpose of the Study:

  • To review the importance of metabolic dysfunction in cancer risk assessment.
  • To highlight mouse models used by the Metabolic Dysfunction and Cancer Risk Program (MeDOC) consortium.
  • To discuss approaches for modeling cancer risk, focusing on onset, latency, and prevention.

Main Methods:

  • Review of preclinical studies, including genetically engineered mouse models, carcinogen administration, and cell/tumor transplantation (allografts/xenografts).
  • Focus on models that approximate cancer risk (onset, latency) rather than progression.
  • Examination of breast and colorectal cancer models associated with obesity.

Main Results:

  • Mouse models are crucial for understanding obesity's role in cancer risk.
  • Specific models allow for the quantification of cancer onset and latency.
  • Findings explore obesity-related cancer risk, prevention, and interception strategies.

Conclusions:

  • Metabolic dysfunction, particularly obesity, is a critical factor in cancer risk.
  • Appropriate preclinical models are essential for studying cancer risk and developing prevention strategies.
  • Further research using models like those in the MeDOC program can advance cancer interception efforts.