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Newly Diagnosed Hemoglobin SC Disease Presenting With Choledocholithiasis With Acute Obstructive Cholangitis: A Case
Daniel T Tran1, Justin J Youn2, Gary Thompson3
1Internal Medicine, Loma Linda University School of Medicine, Loma Linda, USA.
Cureus
|June 13, 2025
Summary
Hemoglobin SC disease (HbSC), often mild, can cause serious complications like acute cholangitis. Early diagnosis of HbSC in high-risk individuals is crucial for timely treatment and improved quality of life.
Area of Science:
- Hematology
- Genetics
Background:
- Sickle cell disease (SCD) encompasses various genetic disorders, including Hemoglobin SS (HbSS) and Hemoglobin SC (HbSC) disease.
- HbSC is typically considered milder than HbSS, often presenting with fewer and less severe complications.
Observation:
- Despite its milder classification, HbSC can be underdiagnosed due to asymptomatic presentation or mild symptoms.
- A case of newly diagnosed HbSC presented with acute cholangitis secondary to choledocholithiasis, a potentially life-threatening condition.
Findings:
- This case highlights that severe, clinically significant complications can arise in individuals with HbSC.
- The presentation of acute cholangitis underscores the potential for serious biliary tract disease in HbSC patients.
Implications:
- Early screening and diagnosis of HbSC in at-risk populations are essential for proactive management.
- Timely intervention may prevent severe complications, reduce healthcare burdens, and enhance the quality of life for HbSC patients.
Keywords:
acute cholangitischoledocholithiasishemoglobin sc diseasehemoglobin ss diseasesickle cell diseaseMore Related Videos
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