Enhanced coagulation index: a potent prognostic indicator for clinical outcomes in non-metastatic breast cancer following surgery and adjuvant therapy
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View abstract on PubMed
Summary
This summary is machine-generated.The APTT/TT ratio can predict breast cancer patient prognosis. Higher APTT/TT ratios are linked to poorer disease-free survival, suggesting its use in treatment assessment.
Area Of Science
- Oncology
- Hematology
- Biochemistry
Background
- Limited research exists on complex coagulation markers and cancer prognosis.
- Single coagulation markers show some correlation with malignant tumor prognosis.
- This study explores complex coagulation markers in nonmetastatic breast cancer outcomes.
Purpose Of The Study
- To investigate the relationship between complex coagulation markers and clinical outcomes in nonmetastatic breast cancer patients.
- To assess the prognostic value of coagulation markers in breast cancer patients receiving comprehensive treatment.
Main Methods
- Retrospective cohort study of 264 breast cancer patients (2016-2018).
- Analysis of patient data from Suqian Hospital, Xuzhou Medical University.
- Utilized Subject-working characteristic curves, X-TILE analysis, and multivariate Cox regression models.
Main Results
- The optimal cut-off for APTT/TT ratio was identified as 1.4.
- A higher APTT/TT ratio (≥1.4) was associated with limited 5-year disease-free survival (DFS).
- Increased APTT/TT ratio (HR=4.057) and lymph node metastases (HR=2.324) were independent prognostic factors for DFS.
Conclusions
- The APTT/TT ratio plays a crucial role in predicting breast cancer prognosis post-treatment.
- Integrating coagulation markers with clinicopathological indices can improve prognostic assessments.
- Findings highlight the clinical utility of the APTT/TT ratio in breast cancer management.
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