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Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
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Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
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Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
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Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

334
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
334
  1. Home
  3. Research Domains
  5. Engineering
  7. Fluid Mechanics And Thermal Engineering
  9. Experimental Methods In Fluid Flow, Heat And Mass Transfer
  11. Ischemia/reperfusion-associated Oxidative Stress Is An Aggravating Factor For Pressure Ulcers.
  1. Home
  3. Research Domains
  5. Engineering
  7. Fluid Mechanics And Thermal Engineering
  9. Experimental Methods In Fluid Flow, Heat And Mass Transfer
  11. Ischemia/reperfusion-associated Oxidative Stress Is An Aggravating Factor For Pressure Ulcers.

Related Experiment Video

Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS
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Visualization of Vascular Ca2+ Signaling Triggered by Paracrine Derived ROS

Published on: December 21, 2011

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Ischemia/reperfusion-associated oxidative stress is an aggravating factor for pressure ulcers.

Eri Murata1, Junichi Fujii2

  • 1Department of Fundamental Nursing, Yamagata University Graduate School of Nursing, 2-2-2 Iidanishi, Yamagata 990-9585, Japan.

Journal of Clinical Biochemistry and Nutrition
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Pressure ulcers (PUs) result from prolonged ischemia and reperfusion injury, damaging cells through oxidative stress. Antioxidants and micronutrients are key for preventing and treating PUs.

Keywords:
ascorbateoxidative stressreactive oxygen speciesskin

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Non-thermal Infrared Light Treatment of Ischemia/Reperfusion Injury and Subsequent Analysis of Macrophage Differentiation
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Non-thermal Infrared Light Treatment of Ischemia/Reperfusion Injury and Subsequent Analysis of Macrophage Differentiation
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Non-thermal Infrared Light Treatment of Ischemia/Reperfusion Injury and Subsequent Analysis of Macrophage Differentiation

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Area of Science:

  • Biomedical Science
  • Wound Healing Research
  • Cellular Biology

Background:

  • Prolonged compression causes ischemia, restricting blood flow and nutrient supply to cells.
  • Pressure ulcers (PUs) are pathological conditions arising from sustained ischemia, leading to tissue damage.
  • Reperfusion following pressure release can cause secondary injury (reperfusion injury) to ischemic tissues.

Purpose of the Study:

  • To explore the role of oxidative stress in the pathogenesis of pressure ulcers.
  • To discuss the potential of micronutrients and antioxidants in preventing and treating pressure ulcers.

Main Methods:

  • Review of scientific literature on pressure ulcer development and oxidative stress.
  • Analysis of the mechanisms linking ischemia/reperfusion injury to cellular damage.
  • Examination of the role of reactive oxygen species (ROS) and inflammation in PU progression.

    • Main Results:

    • Muscle cells are preferentially damaged early in compression due to high aerobic respiration demands.
    • Leukocyte infiltration releases cytokines and ROS, exacerbating inflammation and tissue damage.
    • Oxidative stress, driven by ischemia/reperfusion, is a central factor in pressure ulcer pathogenesis.

    Conclusions:

    • Antioxidant compounds and enzymes are crucial for mitigating damage and preventing PU progression.
    • Micronutrients and antioxidants offer promising avenues for effective PU prevention and treatment strategies.
    • Targeting oxidative stress pathways presents a viable therapeutic approach for managing pressure ulcers.