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Updated: Jun 15, 2025
An Efficient Method for Adenovirus Production
Published on: June 10, 2021
Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024
Guoqing Chen1, Jin Cao2,3, Yingli Qu2
1Key Laboratory of Molecular Biology in Public Health, Yancheng Center for Disease Prevention and Control, Yancheng, China.
Insights
Human adenovirus (HAdV) B3 was the dominant strain infecting children with acute respiratory infections in Yancheng, China, during winter 2023-2024. This study tracked HAdV epidemiology and evolution in pediatric patients.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Human adenovirus (HAdV) is a common cause of acute respiratory infections (ARIs) in children worldwide.
- Understanding the circulating strains and their genetic characteristics is crucial for disease control and prevention.
Purpose of the Study:
- To investigate the epidemiological and evolutionary features of HAdV infections in children in Yancheng, China.
- To identify the predominant HAdV types during the winter of 2023-2024.
Main Methods:
- Collected HAdV-positive throat swab samples from pediatric patients with ARI in Yancheng.
- Amplified and sequenced Hexon, Penton base, and Fiber genes for HAdV typing.
- Performed phylogenetic analysis to determine viral relationships and evolution.
Main Results:
- Identified 170 HAdV-positive samples from children with ARI.
- Successfully sequenced 133 samples, revealing HAdV-B3 as the dominant circulating strain.
- Also identified HAdV strains B21, C1, and C5, indicating diverse HAdV circulation.
Conclusions:
- HAdV-B3 was the primary cause of pediatric respiratory infections in Yancheng during the 2023-2024 winter season.
- The findings highlight the importance of continuous surveillance of HAdV strains for effective public health interventions.
Objective:
To understand the epidemiology and evolutionary characteristics of human adenovirus (HAdV) infecting children in Yancheng, China, during the winter of 2023-2024.
Methods:
HAdV-positive throat swab samples were collected from pediatric patients in Yancheng. The Hexon, Penton base, and Fiber genes were amplified and sequenced for typing and phylogenetic analysis of HAdV.
Results:
170 HAdV-positive samples were collected and identified from children with acute respiratory infection (ARI) in Yancheng. A total of 133 samples were successfully amplified and sequenced for Hexon, Penton base, and Fiber genes. Phylogenetic analysis showed that HAdV-B3 was the dominant circulating strain, and two strains of B21, one strain of C1 and one strain of C5 were also identified.
Conclusion:
During the winter of 2023-2024, HAdV infecting children in Yancheng was mainly the B3 type.
