Related Experiment Video

Updated: Jun 15, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Systematic Review and Meta-Analysis to Explore the Relationship of Increased Homocysteine, Lipid Levels and Lipid

Sonu K Singh1, Roshan K Jha1, Ranjit S Ambad1

  • 1Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.

Journal of Pharmacy & Bioallied Sciences
|June 13, 2025
PubMed

Insights

Elevated homocysteine levels significantly increase the risk of coronary artery disease (CAD). This meta-analysis confirms homocysteine as a key factor in cardiovascular risk assessment.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Epidemiology

Background:

  • Coronary artery disease (CAD) is a major global health concern.
  • Elevated homocysteine is an emerging independent risk factor for CAD.
  • Understanding this link is crucial for public health.

Purpose of the Study:

  • To quantitatively assess the association between homocysteine levels and CAD risk.
  • To pool data from multiple studies for a robust conclusion.
  • To provide evidence for clinical risk stratification.

Main Methods:

  • Comprehensive meta-analysis of 25 relevant studies.
  • Utilized random-effects models to account for heterogeneity.
  • Calculated pooled odds ratios (OR) and 95% confidence intervals (CI).

Main Results:

  • A significant positive association was found between elevated homocysteine and CAD risk.
  • The pooled OR indicated a moderate yet consistent risk increase.
  • Heterogeneity was appropriately managed in the analysis.

Conclusions:

  • Elevated homocysteine is a significant risk factor for coronary artery disease.
  • Findings support integrating homocysteine measurement into cardiovascular risk protocols.
  • This can aid in early detection and prevention strategies.
Abstract

Keywords:
Atherosclerosiscardiovascular riskcoronary artery diseasehomocysteinelipid

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