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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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A longitudinal study of frailty reversibility through a multi-component dementia prevention program
Akihiro Yakabi1, Masahiro Ishizaka1, Miyoko Watanabe1
1Department of Physical Therapy, School of Health Sciences, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara, Tochigi 324-8501, Japan.
Journal of Physical Therapy Science
|June 13, 2025
Summary
A 3-month intervention combining exercise and cognitive training improved processing speed in pre-frail and frail older adults, suggesting potential for frailty reversibility and enhanced cognitive function.
Area of Science:
- Gerontology
- Cognitive Neuroscience
- Public Health
Background:
- Frailty is a significant health concern in older adults, increasing vulnerability to adverse outcomes.
- Identifying interventions to reverse or mitigate frailty is crucial for promoting healthy aging.
Purpose of the Study:
- To evaluate the impact of a combined exercise and cognitive training intervention on pre-frail and frail older adults.
- To assess changes in cognitive function and body composition to explore the reversibility of frailty.
Main Methods:
- A 3-month intervention was conducted with 51 community-dwelling older adults (≥70 years).
- Participants were categorized into Robust and Prefrail/Frail groups using the Kihon Checklist.
- Cognitive function was assessed using the National Center for Geriatrics and Gerontology functional assessment tool; body composition was measured via bioelectrical impedance analysis.
Main Results:
- The Prefrail/Frail group showed significant improvements in processing speed compared to the Robust group.
- No significant changes were observed in other cognitive function measures.
- Body composition changes were not detailed in the provided abstract.
Conclusions:
- Short-term multicomponent interventions may enhance specific cognitive functions in individuals experiencing frailty.
- Further investigation is warranted to determine the long-term efficacy and broader impact of such interventions on frailty.
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