Related Experiment Video
Updated: Jun 15, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
A longitudinal study of frailty reversibility through a multi-component dementia prevention program
Akihiro Yakabi1, Masahiro Ishizaka1, Miyoko Watanabe1
1Department of Physical Therapy, School of Health Sciences, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara, Tochigi 324-8501, Japan.
Abstract:
[Purpose] We evaluated the effects of a multicomponent intervention for pre-frail and frail older adults and assessed changes in cognitive function and body composition to explore frailty reversibility. [Participants and Methods] A total of 51 community-dwelling older adults aged 70 years or older were classified into the Robust (n=28) and Prefrail/Frail groups (n=23) using the Kihon Checklist. A 3-month intervention combining exercise and cognitive training was implemented. Cognitive function was assessed using the National Center for Geriatrics and Gerontology functional assessment tool, and body composition was measured using bioelectrical impedance analysis. [Results] Compared with the Robust group, the Prefrail/Frail group exhibited significantly improved processing speed, whereas other cognitive function measures showed no significant changes. [Conclusion] These findings suggest that short-term intervention may enhance specific cognitive functions associated with frailty. Further research is needed to clarify the long-term effects.
Related Concept Videos
Longitudinal Studies
Longitudinal Research
Alzheimer's Disease: Treatment
Cognitive Development During Adulthood
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

