Related Experiment Video
Updated: Jul 22, 2026
Rat Model of Adhesive Capsulitis of the Shoulder
Published on: September 28, 2018
Basic Science Research in Frozen Shoulder: Current Updates
Jun-Young Kim1, Nitesh Gahlot2, Hyung Bin Park3
1Department of Orthopaedic Surgery, Daegu Catholic University School of Medicine, Daegu, Republic of Korea.
Background:
Frozen shoulder (FS) is a painful and functionally debilitating condition characterized by progressive shoulder stiffness. The etiology and pathomechanism of FS remain unclear but are likely influenced by genetic predisposition, systemic inflammation, and localized shoulder trauma.
Methods:
A comprehensive search was conducted on July 4, 2024, using PubMed, SCOPUS, and Google Scholar. Keywords included "frozen shoulder" and "adhesive capsulitis," with a focus on basic science-related topics.
Results:
Chronic inflammatory conditions in FS trigger a cascade involving cytokines, growth factors, increased extracellular matrix turnover, fibroblast activation, collagen deposition, and reduced matrix degradation, contributing to fibrosis and impaired joint mobility.
Conclusions:
FS is a condition with multifactorial triggering factors that require targeted research to elucidate its mechanisms and identify molecular targets. Basic scientific studies are essential for developing biomarkers and advancing therapeutic strategies.
Related Concept Videos
02:45Responses to Heat and Cold Stress
01:28Factors Affecting Body Temperature
Factors may include:
01:29Decreased Body Temperature
01:14Assessing Body Temperature - Axilla
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
01:26Requirements for Human Life
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
01:26Thermoregulation