From data to insights: a tool for comprehensive Quantification of Continuous Glucose Monitoring (QoCGM)

Continuous glucose monitoring (CGM) has become a important technology in the management and research of both type 1 and type 2 diabetes, providing real-time data on glucose fluctuations that were previously inaccessible with traditional monitoring methods. Numerous analytical tools have been developed for platforms like R and Python to calculate standard metrics and extract insights from CGM data. However, these tools often fail to address the full spectrum of analytical requirements. Furthermore, there is a lack of updated, open-source tools tailored for MATrix LABoratory (MATLAB)-a platform widely used by the research community. To address this gap, we introduce Quantification of Continuous Glucose Monitoring (QoCGM), a comprehensive, open-source post-hoc analytical tool for CGM data specifically designed for MATLAB. A case study involving 324 individuals with insulin-treated type 2 diabetes mellitus (T2DM) demonstrates the utility of QoCGM, highlighting the distinct aspects of glucose dynamics captured by different CGM-derived metrics through an analysis of their coefficients of determination (R ²).