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Updated: Jun 14, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Nitrogen-Centered Organic Persistent Radicals Catalyze Redox-Neutral C─C Bond Forming Reactions
Shrouq Mujahed1, Jaysan Janabel1, Kundan Shaw1
1The Division of Science, Chemistry Program, New York University Abu Dhabi, PO Box 129188, Abu Dhabi, UAE.
Abstract:
We report that nitrogen-centered persistent radicals, Kuhn verdazyls, are effective, tunable ground-state redox organocatalysts for single electron transfer (SET)-initiated radical transformations. Verdazyls uniquely emulate catalytic single-electron shuttling, a hallmark of redox catalysis, without light or external stimuli. They enable redox-neutral C─C bond-forming reactions, such as C─H arylation and C─H trifluoromethylation, typically driven by transition metals, photoredox catalysts, or mechanoredox mediators, while avoiding the self-inhibition that limits organic super electron donors and nitroxides in such applications.
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