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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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  11. Lobetyolin Alleviates Imq‑induced Psoriasis‑like Skin Inflammation By Maintaining The Homeostasis Of The Skin And Inhibiting The Inflammatory Cytokines In Dendritic Cells

Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells

Jianping He1, Chenxi Feng1, Yaohan Xu1

  • 1Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China.

International Journal of Molecular Medicine
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Lobetyolin (LBT) effectively treats psoriasis in mice by regulating skin homeostasis and inhibiting inflammatory pathways. This natural compound shows promise as a novel psoriasis therapy or an adjunct to existing treatments.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Psoriasis is a common inflammatory skin disease characterized by keratinocyte overgrowth and immune cell infiltration.
  • Current treatments like biologics targeting the IL-23/IL-17 axis are effective but have limitations such as recurrence and side effects.
  • Safer and more effective alternatives for psoriasis treatment are needed.

Purpose of the Study:

  • To investigate the potential of Lobetyolin (LBT), a natural compound from Codonopsis pilosula, for treating psoriasis.
  • To explore LBT's mechanisms of action in managing psoriasis-like skin inflammation.

Main Methods:

  • Topical application of LBT on mice with induced psoriasis-like skin inflammation.
  • Analysis of gene expression related to keratinocyte proliferation, differentiation, PPAR signaling, and linoleic acid metabolism.
Keywords:
dendritic cellsinflammatory cytokineslinoleic acid metabolismlobetyolin

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  • Assessment of LBT's effects on cytokine activity and inflammatory signaling pathways (IL-17, TNF, MAPK) in dendritic cells.

    • Main Results:

    • Topical LBT significantly inhibited psoriasis in mice, maintaining skin homeostasis.
    • LBT regulated genes involved in keratinocyte proliferation/differentiation, enhanced the PPAR pathway, and modulated linoleic acid metabolism.
    • LBT suppressed inflammatory cytokine gene expression and key signaling pathways (IL-17, TNF, MAPK) in dendritic cells.

    Conclusions:

    • Topical LBT demonstrates efficacy in reducing imiquimod-induced psoriasis-like skin inflammation.
    • LBT preserves skin homeostasis and inhibits inflammatory cytokines in dendritic cells.
    • LBT is a potential therapeutic candidate for psoriasis or an adjunct therapy to prevent relapse.
    psoriasis
    skin homeostasis