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Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
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Chronic radiation dermatitis in breast cancer patients: pathophysiology, prevention and management strategies, and
Molly A Chakraborty1, Shing Fung Lee2, Henry C Y Wong3
1Rutgers New Jersey Medical School, Newark, NJ, USA.
Annals of Palliative Medicine
|June 13, 2025
Summary
Chronic radiation dermatitis (CRD) after breast cancer radiation therapy (RT) is a progressive skin condition. Further research is needed for standardized prevention and management strategies to improve patient quality of life.
Area of Science:
- Oncology
- Dermatology
- Radiation Oncology
Background:
- Radiation therapy (RT) is a standard breast cancer treatment.
- Chronic radiation dermatitis (CRD) is a progressive, irreversible skin condition occurring >90 days post-RT.
- CRD manifests as pigmentation changes, fibrosis, telangiectasia, ulceration, necrosis, and potential malignancy.
Purpose of the Study:
- To provide a comprehensive literature review on CRD.
- To explore CRD pathophysiology, clinical manifestations, prevention, and management.
- To assess the impact of CRD on quality of life.
Main Methods:
- Comprehensive literature review of existing research on CRD.
- Analysis of reported prevention strategies for acute and chronic radiation dermatitis.
- Review of management techniques for CRD manifestations.
Main Results:
- Limited research exists on CRD incidence and management, with varying study methodologies.
- Prevention strategies for CRD include massage therapy and physical activity.
- Preventing acute radiation dermatitis (ARD) with topical corticosteroids or barrier films may reduce CRD risk.
- Management options for CRD include laser therapy, flap reconstruction, vitamin E, pentoxifylline, and fat grafting.
Conclusions:
- Standardization of CRD scoring and study endpoints is crucial.
- Further research is essential for effective CRD prevention and management.
- Addressing CRD is vital for improving cosmetic outcomes and quality of life for breast cancer survivors.
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