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  11. Nerve Diameter And Dti Parameters Maybe Potential Markers For Clinical Trial In Patients With Charcot-marie-tooth Disease Type 1a

Nerve Diameter and DTI Parameters Maybe Potential Markers for Clinical Trial in Patients With Charcot-Marie-Tooth Disease Type 1A

Yuchen Zhu1, Xingwen Sun2, Dongsheng Fan1,3,4

  • 1Department of Neurology, Peking University Third Hospital, Beijing, Haidian, China.

European Journal of Neurology
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Diffusion tensor imaging (DTI) parameters and nerve diameter can track Charcot-Marie-Tooth disease type 1A (CMT1A) progression. Larger nerve diameters and altered DTI metrics in proximal nerves indicate disease severity.

Area of Science:

  • Neurology
  • Medical Imaging
  • Biophysics

Background:

  • Charcot-Marie-Tooth disease type 1A (CMT1A) is the most prevalent form of CMT, presenting a spectrum from mild to severe symptoms.
  • Magnetic resonance neurography (MRN) and diffusion tensor imaging (DTI) offer potential for non-invasive disease assessment.

Purpose of the Study:

  • To evaluate DTI parameters and proximal nerve diameters as potential biomarkers for CMT1A progression.
  • To correlate imaging findings with clinical severity in CMT1A patients.

Main Methods:

  • Prospective study of 45 CMT1A patients categorized into mild, moderate, and severe subgroups based on muscle strength.
  • MRN and DTI assessed L4-L5 nerve roots, femoral nerve (FN), and sciatic nerve (SN) diameters and DTI metrics (FA, MD, AD, RD).
  • Comparison between CMT1A patients and healthy controls (HCs), and longitudinal follow-up of 19 patients over 15 months.
Keywords:
Charcot–Marie–Tooth disease type 1Adiffusion tensor imagingmagnetic resonance imagingsciatic nerve

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Main Results:

  • Significantly larger diameters of L4 nerve roots and SN observed in severe CMT1A cases compared to mild cases and HCs.
  • Reduced fractional anisotropy (FA) and increased mean diffusivity (MD) and axial diffusivity (AD) were noted in severe cases, particularly in SN and L4 nerve roots.
  • Significant changes in nerve diameters and DTI parameters (FA, MD, AD, RD) were observed after the follow-up period.

Conclusions:

  • Nerve diameter and DTI metrics (FA, MD, AD) are sensitive indicators of CMT1A severity and progression.
  • Proximal nerve roots, specifically the sciatic nerve (SN) and L4 nerve roots, show prominent changes and may serve as valuable indices for monitoring the disease.
spinal nerve root