Therapeutic Potential of PSC-derived Cell Transplantation in Parkinson's Disease: A Systematic Review and
Aliasghar Karimi1, Zahra Shiri2, Reza Tabrizi3,4
1Research Center for Neuromodulation and Pain, NAB Pain Clinic, Shiraz University of Medical Sciences, Shiraz, Iran.
Parkinson's disease cell therapy using pluripotent stem cell-derived dopaminergic progenitors shows significant promise. This approach effectively improves motor function in animal models, offering hope for halting disease progression and enhancing patient quality of life.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Cell Therapy
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder impacting motor function.
- Current treatments offer temporary symptomatic relief, with patients facing progressive disability.
- Cell replacement therapy aims to restore dopaminergic neurons, potentially halting PD progression.
Purpose of the Study:
- To systematically review preclinical data on pluripotent stem cell (PSC)-derived dopaminergic (DA) progenitor efficacy in PD animal models.
- To assess the therapeutic potential for future human clinical trials.
Main Methods:
- Comprehensive literature search of PubMed, Scopus, and Web of Science for studies published before August 14th, 2023.
- Inclusion of 46 studies after rigorous screening.
- Quality assessment using CAMARADES and SYRCLE methodologies.
Main Results:
- Cell therapy demonstrated significant improvement in motor dysfunction across rodent and non-human primate (NHP) PD models.
- Methodological limitations were identified in some studies, though overall risk of bias was low.
Conclusions:
- PSC-based cell therapy is a promising strategy for Parkinson's disease.
- This therapy may halt disease progression, improve motor symptoms, and enhance quality of life for PD patients.
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