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Related Concept Videos

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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Dentistry
  9. Periodontics
  11. Systemic, Lifestyle And Environmental Modifying Factors In The Pathogenesis Of Periodontitis.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Dentistry
  9. Periodontics
  11. Systemic, Lifestyle And Environmental Modifying Factors In The Pathogenesis Of Periodontitis.

Related Experiment Video

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis.

Groeger Sabine Elisabeth1,2, Zhou Yuxi3, Yong Jiawen4

  • 1Department of Periodontology, Dental School, Justus-Liebig-University of Giessen, Giessen, Germany.

Journal of Periodontal Research
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Periodontitis, a gum disease affecting millions, involves tissue destruction due to microbial imbalance and immune responses. Various systemic, lifestyle, and environmental factors significantly influence its development and progression.

Keywords:
environmental factorslifestyle factorsmodifying factorspathogenesis of periodontitis

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Area of Science:

  • Periodontology
  • Immunology
  • Microbiology

Background:

  • Periodontitis is a prevalent chronic inflammatory condition affecting periodontal tissues.
  • Characterized by gingival inflammation, attachment loss, bone resorption, and potential tooth loss.
  • Pathogenesis involves dysbiotic microbiota and aberrant immune responses, modulated by various factors.

Purpose of the Study:

  • To review the mechanistic aspects linking periodontitis pathogenesis to influencing factors.
  • To supplement existing knowledge on periodontitis progression.
  • To categorize influencing factors based on evidence level.

Main Methods:

  • Literature review of studies on periodontitis and associated factors.
  • Analysis of mechanistic links between pathogenesis and influencing factors.
risk factor
systemic factors
  • Classification of factors into predisposing, risk indicators, and risk factors.

    • Main Results:

    • Identified systemic, lifestyle, and environmental factors influencing periodontitis.
    • Classified factors: predisposing (age, diet, alcohol, physical activity, socioeconomic status), risk indicators (obesity, osteoporosis, cardiovascular diseases, mental health, stress, sleep disorders), and risk factors (smoking, diabetes mellitus).
    • Highlighted the interplay between microbiota, immune response, and these factors in disease progression.

    Conclusions:

    • Periodontitis development and progression are multifactorial.
    • Understanding these diverse factors is crucial for comprehensive management and prevention strategies.
    • Further research into the mechanistic links can refine therapeutic approaches.