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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Reproductive Medicine
  9. Foetal Development And Medicine
  11. Exploring The Vertical Transmission Of Exosomes In Diagnostic And Therapeutic Targets For Pregnancy Complications

Exploring the Vertical Transmission of Exosomes in Diagnostic and Therapeutic Targets for Pregnancy Complications

Shrikrishna Bhagat1, Rakshith Hanumanthappa2, Ketki Bhokare3

  • 1Institute of Life Sciences, Bhubaneswar 751023, Odisha, India.

ACS Biomaterials Science & Engineering
|June 13, 2025

Related Experiment Videos

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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Isolation and Characterization of Microvesicles from Peripheral Blood
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Isolation and Characterization of Microvesicles from Peripheral Blood

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View abstract on PubMed

Summary
This summary is machine-generated.

Placental exosomes, tiny vesicles carrying biomolecules, are crucial for healthy pregnancies. Their altered levels and composition may indicate complications like preeclampsia and gestational diabetes.

Area of Science:

  • Reproductive Biology
  • Cellular Biology
  • Biochemistry

Background:

  • The placenta facilitates complex maternal-fetal exchanges during pregnancy.
  • Placental exosomes are extracellular vesicles containing proteins, lipids, DNA, and microRNA.
  • These exosomes influence maternal cellular functions, immune tolerance, and placental growth.

Purpose of the Study:

  • To review the significance of placenta-derived exosomes in pregnancy.
  • To explore their role in normal and complicated pregnancies.
  • To discuss their potential as biomarkers and therapeutic targets for pregnancy complications.

Main Methods:

  • Literature review focusing on placenta-derived exosomes.
  • Analysis of exosome composition, concentration, and bioactivity.
Keywords:
biomarker discoveryexosomesgestational diabetesimmunomodulation

Related Experiment Videos

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

775
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

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Isolation and Characterization of Microvesicles from Peripheral Blood
06:03

Isolation and Characterization of Microvesicles from Peripheral Blood

Published on: January 6, 2017

23.0K
  • Exploration of advanced techniques for exosome analysis.

    • Main Results:

    • Placental exosomes are vital for normal placental development and maternal immune tolerance.
    • Variations in placental exosome quantity, quality, and composition are linked to gestational diabetes, preeclampsia, and infections.
    • Exosomes are being investigated for their role in pregnancy complication etiology and progression.

    Conclusions:

    • Placenta-derived exosomes play a critical role in maternal-fetal interactions.
    • Exosomes hold promise as biomarkers for early diagnosis of pregnancy complications.
    • Further research using precise methodologies is needed to determine clinical utility.
    placental EVs
    preeclampsia