Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

26
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
26
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Cancer Survival Analysis01:21

Cancer Survival Analysis

334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Depression And Inflammation Predict Depression Trajectory Of Non-small Cell Lung Cancer Patients

Depression and Inflammation Predict Depression Trajectory of Non-Small Cell Lung Cancer Patients

Kylie R Park1, Peter G Shields, John Myers

  • 1Department of Psychology, 1835 Neil Ave., Ohio State University, Columbus, Ohio 43210, USA (Park); Center for Tobacco Research, Ohio State University Comprehensive Cancer Center, 3650 Olentangy River Road, Suite 420, Columbus, Ohio 43210, USA (Shields); Department of Biomedical Informatics and Center for Biostatistics, 1800 Cannon Drive, College of Medicine, Columbus, OH 43210, USA (Myers); Center for Tobacco Research, Ohio State University Comprehensive Cancer Center, 3650 Olentangy River Road, Suite 420, Columbus, Ohio 43210, USA (Reisinger); Department of Psychology, 1885 Neil Ave., Ohio State University, Columbus, Ohio 43210, USA (Andersen).

Biopsychosocial Science and Medicine
|June 13, 2025

Related Experiment Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

400
Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

6.9K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.0K

View abstract on PubMed

Summary
This summary is machine-generated.

Co-occurring depression and high systemic inflammation in lung cancer patients predict worsening depressive symptoms over time. This highlights a new biobehavioral marker for identifying persistent depression in cancer care.

Area of Science:

  • Oncology
  • Psychiatry
  • Immunology

Background:

  • Depression and systemic inflammation are linked to poor outcomes in lung cancer patients.
  • The interaction between these factors and psychological morbidity is not well understood.
  • This study investigates the combined impact of depression and inflammation on depressive symptom trajectories.

Purpose of the Study:

  • To determine if the co-occurrence of depression and systemic inflammation predicts a worsened trajectory of depressive symptoms in lung cancer patients.
  • To explore the interaction of depression and inflammation as biomarkers for psychological morbidity.
  • To identify potential biobehavioral metrics for depression maintenance in lung cancer.

Main Methods:

  • An observational longitudinal cohort study (N=182) of advanced non-small cell lung cancer patients.
Keywords:
advanced lung cancer inflammation indexcancerdepressioninflammation

Related Experiment Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

400
Predictive Immune Modeling of Solid Tumors
08:50

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

6.9K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.0K
  • Assessed depressive symptoms (Patient Health Questionnaire-9) and systemic inflammation (Advanced Lung Cancer Inflammation Index) at diagnosis and monthly for 8 months.
  • Subdivided patients into four cohorts based on validated cutoffs for depression and inflammation.

    • Main Results:

    • Depressive symptoms did not significantly change over time for the overall cohort (P=0.26).
    • A significant interaction effect was observed for the "Depression+Inflammation" cohort, indicating an elevated depression trajectory (P=0.001).
    • This suggests that patients with both high depression and high inflammation experienced worsening depressive symptoms.

    Conclusions:

    • Co-occurring depression and systemic inflammation predict a worsening trajectory of depressive symptoms in lung cancer patients.
    • This finding contributes to understanding depression pathophysiology in cancer.
    • The study proposes a novel biobehavioral metric for identifying persistent depression in this population.
    neutrophil-to-lymphocyte ratio
    systemic inflammatory response