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  11. Oxygen And Immunity To Leishmania Infection

Oxygen and immunity to Leishmania infection

Bridget A Bowman1, Fernanda O Novais1

  • 1Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

Infection and Immunity
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Oxygen levels and hypoxia-inducible factor (HIF) critically impact immune cells in leishmaniasis. Understanding this oxygen-HIF interplay is key to developing new treatments for this parasitic disease.

Area of Science:

  • Immunology
  • Parasitology
  • Cellular Physiology

Background:

  • Leishmaniasis presents diverse clinical outcomes, from skin lesions to visceral disease.
  • Infected tissues in leishmaniasis often exhibit hypoxia, a state of low oxygen.
  • Oxygen availability is crucial for immune regulation, but its role in leishmaniasis is not fully understood.

Purpose of the Study:

  • To review existing literature on oxygen availability and HIF signaling in leishmaniasis.
  • To elucidate how hypoxia influences the immune response in leishmaniasis.
  • To identify knowledge gaps and guide future research on therapeutic strategies.

Main Methods:

  • Literature review of published studies on leishmaniasis, oxygen, and HIF.
  • Analysis of the role of hypoxia-inducible factor (HIF) in immune cell function.
Keywords:
hypoxiaimmune responsesleishmaniasisoxygen

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  • Synthesis of findings on oxygen's impact on myeloid cell responses.

    • Main Results:

    • Published studies underscore the critical role of oxygen and HIF in leishmaniasis immunity.
    • Hypoxia-inducible factor (HIF) signaling is particularly important in myeloid cells during infection.
    • Oxygen availability significantly shapes the immune landscape in leishmaniasis.

    Conclusions:

    • Oxygen availability and HIF signaling are central regulators of immune responses in leishmaniasis.
    • Further research is needed to fully understand the interplay between oxygen, immunity, and disease progression.
    • Targeting oxygen-dependent pathways may offer novel therapeutic avenues for leishmaniasis.
    parasites