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Investigating hormonal imbalances in aggressive periodontitis: a scoping review
Zahra Khorshidi Asl1, Fatemeh Farshad2, Farnaz Jafari3
1Students Research Committee, Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
Hormones (Athens, Greece)
|June 13, 2025
Summary
Hormone imbalances, including melatonin, cortisol, and vitamin D, are linked to aggressive periodontitis. Further research is needed to understand the complex interplay and potential therapeutic applications of hormones in this condition.
Area of Science:
- Endocrinology
- Periodontology
- Biomedical Science
Background:
- Aggressive periodontitis is a severe inflammatory condition affecting the gums.
- Hormonal factors are increasingly implicated in the pathogenesis of various inflammatory diseases.
Purpose of the Study:
- To systematically review and consolidate current literature on the role of hormones in aggressive periodontitis.
- To identify hormones with established links and those requiring further investigation in aggressive periodontitis.
Main Methods:
- Systematic literature search conducted in July 2024 across major scientific databases (PubMed, Scopus, Web of Science, Google Scholar).
- Keywords included 'aggressive periodontitis' and various hormone names (e.g., melatonin, cortisol, vitamin D, growth hormone).
- Inclusion criteria focused on original research; exclusions included reviews, case reports, and conference abstracts.
Main Results:
- Identified 27 relevant studies from 258 initial records.
- Evidence supports hormonal imbalances in melatonin, growth factors, adrenomedullin, osteocalcin, cortisol, and vitamin D in aggressive periodontitis.
- Controversy persists regarding the specific roles of certain hormones in periodontitis pathology.
Conclusions:
- Hormonal dysregulation is associated with aggressive periodontitis, though specific mechanisms require elucidation.
- Significant need for further research to explore the intricate relationship between hormones and aggressive periodontitis.
- Potential for novel hormone-based therapeutic strategies in managing aggressive periodontitis.
