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Related Experiment Video

Updated: Jun 14, 2025

Experimental Model of Ligature-Induced Peri-Implantitis in Mice
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Peri-implantitis Risk Assessment (PiRA) Part 1: Umbrella Review of a Multifactorial Disease with Many Risk Factors.

Mihai Tarce, Marc Quirynen

    The International Journal of Oral & Maxillofacial Implants
    |June 13, 2025
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    Summary

    Identifying patient risk factors for peri-implantitis is crucial. An objective assessment can guide treatment decisions and encourage lifestyle changes to mitigate risks associated with dental implants.

    Keywords:
    GBRabutment materialbiofilmbleeding on probingbruxismcement remnantsetiologyfull edentulismgenotypeimplant placement timingimplant surface roughnesskeratinized tissuemicrobiologymulticausalityoral hygienepartial edentulismperi-implantitisperi-implantitis confounding factorsperiodontitisrecall compliancesmokingsupportive periodontal therapy

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    Area of Science:

    • Dental Implantology
    • Periodontology
    • Biomaterials Science

    Background:

    • Peri-implantitis poses a significant threat to the long-term success of dental implants.
    • Pre-operative patient assessment is vital for predicting and preventing peri-implantitis.
    • Understanding patient-specific risk factors is key to personalized implant therapy.

    Purpose of the Study:

    • To conduct an umbrella review identifying patient-related risk factors for peri-implantitis.
    • To assess the relative impact of identified risk factors using odds ratios/relative risks.
    • To explore potential treatment-related confounders influencing peri-implantitis development.

    Main Methods:

    • Umbrella review methodology.
    • Systematic search for patient-related risk factors and their impact (OR/RR).
    • Investigation of treatment-related confounders for peri-implantitis.

    Main Results:

    • Ten patient-related risk factors for peri-implantitis were identified.
    • Risk factors include modifiable (smoking, plaque control) and non-modifiable (history of periodontitis, systemic diseases) elements.
    • Significant variability in the reported impact of risk factors across reviews, highlighting potential for misinterpretation.

    Conclusions:

    • Peri-implantitis etiology is complex and multifactorial.
    • Numerous patient-related risk factors and treatment confounders contribute to peri-implantitis.
    • Objective pre-operative assessment is essential for risk stratification and patient management.