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Sustained release theophylline for the forgetful asthmatic
Annals of Allergy
|October 1, 1985
Summary
Theophylline levels were compared for asthmatic patients. Theodur 100-mg tablets achieved higher initial theophylline levels than Theodur 200-mg, potentially benefiting forgetful patients.
Area of Science:
- Pharmacology
- Clinical Pharmacy
Background:
- Asthma management requires consistent theophylline levels within the therapeutic range (10-20 µg/mL).
- Forgetful, medication-dependent asthmatics often start treatment below therapeutic levels, impacting efficacy.
Purpose of the Study:
- To evaluate theophylline pharmacologic strategies for forgetful, medication-dependent asthmatics.
- To compare the dosing profiles of Theodur and Slophyllin Gyrocap.
- To assess the impact of different Theodur dosages on serum theophylline levels.
Main Methods:
- A multiple-dose 28-hour study compared Theodur and Slophyllin Gyrocap starting from 0 µg/mL.
- A single-dose 12-hour study compared Theodur 100-mg and 200-mg tablets.
Main Results:
- Theodur demonstrated comparable or higher theophylline levels at 2, 8, and 24 hours compared to Slophyllin Gyrocap.
- Theodur 100-mg tablets produced higher initial theophylline levels within the first nine hours than Theodur 200-mg tablets.
Conclusions:
- Theodur appears effective in achieving therapeutic theophylline levels for asthmatics.
- Theodur 100-mg tablets may be a suitable option for forgetful asthmatics, balancing efficacy with potential fluctuations.