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Updated: Jun 15, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Total Synthesis of Pedopeptin C
Michael J Lambrecht1, Ying Lu2, Mary Kate Alexander3
1Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Abstract:
The pedopeptins are a class of antibiotics that have been reported to retain activity against bacterial strains that are resistant to the polymyxins, a class of antibiotics of last resort. Despite this promising activity, the pedopeptins represent synthetically challenging targets due to the dehydroamino acid (E)-2-aminobut-2-enoic acid ((E)-ΔAbu) contained in their structure. Here we show an optimized synthesis of a lead member of this class, pedopeptin C, and describe its antibacterial activity.

