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  11. Impact Of Aphasia On Verbal Memory: Insights From The Selective Anesthesia For Functional Evaluation

Impact of aphasia on verbal memory: insights from the Selective Anesthesia for Functional Evaluation

Hana Kikuchi1, Shin-Ichiro Osawa2, Kazuo Kakinuma1

  • 11Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai.

Journal of Neurosurgery
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Aphasia induced during the Wada test significantly lowers verbal memory scores. Selective anesthesia for functional evaluation (SAFE) may offer a more accurate assessment of memory function in epilepsy patients.

Area of Science:

  • Neurology
  • Neuropsychology
  • Epilepsy Research

Background:

  • The Wada test is standard for evaluating memory decline before epilepsy surgery.
  • Anesthetic infusion in the Wada test can cause aphasia, potentially affecting verbal memory assessment.
  • The precise impact of aphasia on Wada test verbal memory scores requires further verification.

Purpose of the Study:

  • To quantify the effect of aphasia on verbal memory during selective anesthesia of the middle cerebral artery (M1) area.
  • To compare verbal and visual memory performance after left versus right M1 infusions.
  • To assess the utility of Selective Anesthesia for Functional Evaluation (SAFE) in epilepsy patient evaluation.

Main Methods:

  • Retrospective analysis of Selective Anesthesia for Functional Evaluation (SAFE) in drug-resistant epilepsy patients (May 2018-Dec 2023).
Keywords:
Wada testanterior temporal lobectomyepilepsy surgeryfunctional neurosurgery

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  • Cognitive tasks (verbal and visual memory) administered pre- and post-anesthetic infusion.
  • Comparison of memory scores between left and right M1 infusions in patients with left language dominance.

    • Main Results:

    • Left M1 infusions induced aphasia without significant consciousness impairment.
    • Verbal memory scores were significantly lower following left M1 (language-dominant hemisphere) infusions compared to right M1 infusions.
    • Visual memory scores remained comparable between left and right M1 infusions.

    Conclusions:

    • Aphasia during stimulus encoding, as induced by left M1 infusion, significantly impairs verbal memory.
    • The Wada test may provide inaccurate memory assessments due to aphasic interference.
    • SAFE demonstrates potential for reducing aphasic interference, enabling more precise memory evaluation for epilepsy surgery candidacy.
    memory lateralization
    verbal memory