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  1. Home
  3. The Role Of Tumor-associated Endothelial Cells In Malignant Progression And Immune Evasion Of Liver Cancer.
  1. Home
  3. The Role Of Tumor-associated Endothelial Cells In Malignant Progression And Immune Evasion Of Liver Cancer.

Related Experiment Video

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The role of tumor-associated endothelial cells in malignant progression and immune evasion of liver cancer.

Shuangpeng Pu1, Tianguang Liu1, Yuan Gao1

  • 1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.

International Immunopharmacology
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Tumor-associated endothelial cells (TECs) in hepatocellular carcinoma (HCC) promote malignant progression by altering blood vessels and suppressing immune responses. Targeting these TECs offers new precision therapy strategies for HCC.

Keywords:
Hepatocellular carcinomaImmunosuppressiveTherapeutic approachesTumor microenvironmentTumor progressionTumor-associated endothelial cells

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Area of Science:

  • Hepatocellular Carcinoma (HCC) Pathogenesis
  • Tumor Microenvironment (TME) Biology
  • Endothelial Cell Biology and Immunology

Background:

  • Hepatocellular carcinoma (HCC) progression is influenced by both tumor genetics and the tumor microenvironment (TME).
  • Tumor-associated endothelial cells (TECs), a key TME component, significantly drive HCC advancement.
  • TECs contribute to HCC by promoting abnormal vascularization and immune suppression.

Purpose of the Study:

  • To systematically review the molecular mechanisms of hepatic endothelial cell to TEC transition in HCC.
  • To identify TEC subtypes involved in tumor angiogenesis and immune evasion.
  • To elucidate TEC crosstalk with immunosuppressive factors and highlight clinical implications.

Main Methods:

  • Systematic review of literature on TECs in HCC.
  • Analysis of molecular mechanisms driving TEC differentiation.
  • Identification of TEC-mediated pathways in angiogenesis and immune modulation.
  • Review of TEC-specific biomarkers and clinical trials targeting TECs.

    • Main Results:

    • TECs create a pro-tumorigenic niche through disordered vascular networks and immunosuppressive factor secretion.
    • Specific TEC subtypes mediate tumor angiogenesis and immune evasion in HCC.
    • TECs crosstalk with immunosuppressive components within the TME.

    Conclusions:

    • Understanding TECs' role in HCC progression is crucial for developing effective therapies.
    • Targeting the TEC-TME-immune axis presents a promising strategy for precision medicine in HCC.
    • Further research into TEC-specific biomarkers and therapeutic targets is warranted.