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  1. Home
  3. Vegfb167 Drives Tumor Progression By Modulating The Immune Microenvironment.
  1. Home
  3. Vegfb167 Drives Tumor Progression By Modulating The Immune Microenvironment.

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VEGFB167 drives tumor progression by modulating the immune microenvironment.

Yaowu Zheng1, Quangang Chen2, He Zhang2

  • 1Transgenic Research Center, Northeast Normal University, Changchun, Jilin 130024, China.

International Immunopharmacology
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Vascular endothelial growth factor B (VEGFB) isoform 167 significantly promotes tumor growth and metastasis. Targeting VEGFB offers a promising therapeutic strategy for VEGFB-sensitive cancers.

Keywords:
MacrophageSTAT3Tumor microenvironmentVEGFBVEGFR1

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Vascular endothelial growth factor B (VEGFB) is a member of the VEGF family, sharing the VEGFR1 receptor with VEGFA.
  • VEGFB exists in two isoforms, VEGFB167 and VEGFB186, with distinct biological roles that are not well understood.
  • Understanding VEGFB isoform-specific functions is crucial for cancer research.

Purpose of the Study:

  • To investigate the isoform-specific functions of VEGFB in tumorigenesis.
  • To elucidate the role of VEGFB in tumor growth, metastasis, and the tumor microenvironment.

Main Methods:

  • Utilized transgenic mouse models with VEGFB overexpression (aP2-Vegfb167, aP2-Vegfb186) and knockout (Vegfb-/-).
  • Employed tumor cell lines including B16-F10, U14, and LLC.
  • Analyzed the impact of VEGFB on tumor-associated macrophages (TAMs) and anti-tumor immunity.

    • Main Results:

    • VEGFB167 was identified as a potent promoter of tumor growth.
    • VEGFB inactivation significantly retarded tumor growth and metastasis.
    • VEGFB deficiency shifted TAMs from an M2 (pro-tumor) to an M1 (anti-tumor) phenotype, enhancing anti-tumor immunity.
    • VEGFB's impact on tumor progression exceeded that of VEGFA.

    Conclusions:

    • VEGFB167 is a key regulator of tumor progression.
    • Targeting VEGFB signaling presents a novel therapeutic strategy for VEGFB-sensitive cancers.
    • VEGFB inhibition enhances anti-tumor immunity by modulating TAM polarization.