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Design, fluorescent sensing, and biological activity of 1-oxo-1H-phenalene-2,3-dicarbonitrile (OPD) derivatives
Pei Huang1, Jin Liu2, Jiufu Lu2
1Shaanxi Province Key Laboratory of Catalysis, School of Chemical & Environmental Science, Shaanxi University of Technology, Hanzhong 723000, P. R. China; Department of Biology, Centre of Molecular and Environmental Biology, University of Minho, Braga, Portugal.
Abstract:
1-Oxo-1H-phenalene-2,3-dicarbonitrile (OPD) derivatives are pivotal in biomedicine, particularly for applications in fluorescent sensing, biological imaging, and cancer therapy. Their appealing properties, which include excellent optical characteristics, ease of functionalization, modulation of apoptosis, and anticancer effects, have led to the development of a diverse range of OPD derivatives for both analytical and biomedical applications. This review offers a comprehensive overview of the structural features, optical properties, biological activities, and practical applications of OPD and its derivatives. These OPD derivatives exhibit significant potential for advancements in biosensing and antitumor therapies.
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