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Related Concept Videos

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Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Updated: Jun 16, 2025

A Sensitive Method to Quantify Senescent Cancer Cells
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Senescence in cancer.

Manuel Colucci1, Miles Sarill2, Martino Maddalena1

  • 1Institute of Oncology Research, Bellinzona, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.

Cancer Cell
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a cell-cycle arrest state, protects against damaged cells but contributes to aging and cancer. This review examines senescence

Keywords:
AI-approaches for senescencePICSSASP modulatorscancerhallmarks of senescenceoncogene-induced senescenceprosenescencesenescencesenescence immune systemsenescence in tumor microenvironmentsenolyticssenomorphictherapy-induced senescence

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Area of Science:

  • Cellular and Molecular Biology
  • Oncology
  • Aging Research

Background:

  • Cellular senescence is a stable cell-cycle arrest triggered by stress, acting as a tumor suppressor.
  • Accumulated senescent cells are linked to age-related diseases and cancer progression.
  • Senescence has a dual role in cancer, potentially inhibiting or promoting tumor development via the senescence-associated secretory phenotype (SASP).

Purpose of the Study:

  • To review the multifaceted role of cellular senescence in cancer.
  • To explore the interactions between senescent cells, tumor cells, stroma, and the immune system.
  • To discuss therapeutic strategies targeting senescent cells and AI-driven detection methods.

Main Methods:

  • Literature review of cellular senescence in the context of cancer.
  • Analysis of the dual role of senescence in tumor initiation and progression.
  • Exploration of therapeutic interventions and artificial intelligence (AI) applications.

Main Results:

  • Senescence can suppress tumors by arresting damaged cell proliferation.
  • The SASP secreted by senescent cells can promote tumor growth and immune evasion.
  • Senescence outcomes in cancer are highly context-dependent, influenced by the tumor microenvironment.

Conclusions:

  • Cellular senescence presents a complex, context-dependent role in cancer biology.
  • Targeting senescent cells offers potential therapeutic avenues for cancer treatment.
  • AI holds promise for improving the detection and characterization of senescent cells in oncology.