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Loading curcumin on TiO2nanotubes to improve surface biological activity.

Hanyu Peng1,2, Jun Tan3, Xiao Li3,2

  • 1Department of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.

Biomedical Materials (Bristol, England)
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Titanium implants modified with curcumin-loaded TiO2 nanotubes enhance bone integration. This surface modification promotes mesenchymal stem cell proliferation and osteogenic differentiation, offering a promising approach for bioactive dental implants.

Keywords:
TiO2 nanotubes arraycurcuminosteogenesissurface modification of titanium

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Titanium implants are widely used in dentistry but can benefit from enhanced bioactivity for better bone integration.
  • Curcumin, a natural compound, possesses anti-inflammatory and bone healing properties.
  • Surface modification of titanium can improve its interaction with bone cells.

Purpose of the Study:

  • To create a composite modification of pure titanium surfaces using electrochemical anodic oxidation and curcumin drug coating.
  • To enhance the bioactivity of titanium implant surfaces for improved early bone integration.
  • To investigate the effects of this surface modification on bone marrow mesenchymal stem cells (BMSCs) in vitro.

Main Methods:

  • Titanium surfaces were modified via electrochemical anodic oxidation and curcumin coating.
  • Surface characterization included SEM, AFM, XPS, and contact angle analysis.
  • In vitro studies involved cell viability (CCK-8), adhesion, live/dead staining, osteogenic differentiation assays (ALP, PCR, mineralization staining), and drug release analysis.

Main Results:

  • Curcumin-loaded titanium dioxide (TiO2) nanotubes were successfully prepared on titanium surfaces.
  • The modified surfaces exhibited favorable physical properties, including corrosion resistance, mechanical strength, and hydrophilicity, along with effective curcumin release.
  • In vitro experiments showed enhanced BMSC adhesion, proliferation, and osteogenic differentiation on the modified surfaces, demonstrating good biocompatibility.

Conclusions:

  • The composite modification of titanium with TiO2 nanotubes and curcumin is effective in enhancing implant bioactivity.
  • This approach significantly promotes BMSC proliferation and osteogenic differentiation, indicating potential for improved bone integration.
  • The findings provide a strong foundation for developing advanced bioactive implants for dental applications.