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Related Concept Videos

Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

162
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
162
Cancer Survival Analysis01:21

Cancer Survival Analysis

334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Cancer Therapy (excl. Chemotherapy And Radiation Therapy)
  11. Comparison Of Survival And Recurrence Between Colonic And Rectal Tumors After Resection In T1 Colorectal Cancer: Long-term Cohort Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Cancer Therapy (excl. Chemotherapy And Radiation Therapy)
  11. Comparison Of Survival And Recurrence Between Colonic And Rectal Tumors After Resection In T1 Colorectal Cancer: Long-term Cohort Study.

Related Experiment Video

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

231

Comparison of survival and recurrence between colonic and rectal tumors after resection in T1 colorectal cancer: long-term cohort study.

Taishi Okumura1, Kinichi Hotta2, Kenichiro Imai2

  • 1Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan; Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan.

Gastrointestinal Endoscopy
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

T1 rectal cancer resections show higher recurrence than colonic resections in high-risk cases. Vigilant surveillance is crucial for high-risk T1 rectal cancers, especially those with venous invasion or high budding grade.

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Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Colorectal Cancer Research

Background:

  • The impact of lesion location on recurrence after T1 colorectal cancer (CRC) resection is not well understood.
  • This study compares survival and recurrence rates between colonic and rectal tumors following T1 CRC resection.

Purpose of the Study:

  • To evaluate differences in survival and recurrence rates based on tumor location (colon vs. rectum) in patients with T1 colorectal cancer.
  • To identify risk factors associated with recurrence in T1 colorectal cancer resections.

Main Methods:

  • Retrospective review of 987 patients who underwent T1 CRC resection.
  • Patients were stratified into low-risk (Group A), high-risk after endoscopic resection (ER) only (Group B), and high-risk after surgical resection (SR) or ER and SR (Group C) based on pathological risk factors.
  • Comparison of survival and recurrence rates between colonic and rectal tumors within each risk group.

    • Main Results:

    • No significant differences in disease-specific survival (DSS) or recurrence were observed between colonic and rectal tumors in low-risk (Group A) and high-risk ER-only (Group B) groups.
    • In high-risk surgical resection (Group C), rectal lesions exhibited significantly higher cumulative recurrence (4.8% vs. 1.1%) and lower DSS rates (98.2% vs. 99.8%) compared to colonic lesions.
    • Independent recurrence risk factors in Group C included rectal tumor location (HR, 3.25), venous invasion (HR, 9.40), and high budding grade (BD) (HR, 3.05).

    Conclusions:

    • T1 rectal cancer carries a worse prognosis than T1 colonic cancer following high-risk lesion surgical resection.
    • Close monitoring and surveillance are recommended for high-risk T1 rectal cancers, particularly those with venous invasion or a high budding grade.