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A complete procedure of testing the hypothesis about a population mean is explained here.
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  11. Bioavailability Of Different Sources And Doses Of Zinc Using Stable Isotopes In Weaned Male Holstein Calves

Bioavailability of different sources and doses of zinc using stable isotopes in weaned male Holstein calves

H A Tucker1

  • 1Novus International Inc., Chesterfield, MO 63005.

Journal of Dairy Science
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Organic zinc methionine hydroxy analog chelate (Zn-MHAC) showed greater bioavailability than inorganic zinc sulfate (Zn-SO) in Holstein calves. Stable isotopes effectively tracked zinc absorption and tissue enrichment, confirming Zn-MHAC

Area of Science:

  • Ruminant Nutrition and Trace Mineral Bioavailability

Background:

  • Trace minerals are crucial for ruminant health and productivity.
  • Accurate dietary formulation requires understanding the bioavailability of different trace mineral sources.
  • Stable isotopes offer a potential method for assessing mineral bioavailability.

Purpose of the Study:

  • To evaluate stable isotopes as markers for trace mineral bioavailability.
  • To compare the bioavailability of inorganic zinc sulfate (Zn-SO) versus organic zinc methionine hydroxy analog chelate (Zn-MHAC) in Holstein calves.

Main Methods:

  • Eighteen Holstein calves were used in a randomized complete block design.
  • Calves received a basal diet and were administered pulse doses of 0, 4, or 8 mg of Zn from either Zn-SO or Zn-MHAC.
  • Blood and tissue samples were collected over 72 hours post-administration to measure stable isotope enrichment (67Zn and 70Zn).
Keywords:
Znbioavailabilitystable isotopes

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Main Results:

  • Plasma zinc enrichment area under the curve increased significantly with higher zinc doses (8 mg > 4 mg > 0 mg).
  • Zinc methionine hydroxy analog chelate (Zn-MHAC) resulted in significantly greater tissue enrichment compared to zinc sulfate (Zn-SO) in multiple tissues (abomasum, duodenum, hoof, ileum, lung, omasum, reticulum, skin, spleen, metatarsal bone).
  • Higher zinc doses (8 mg) led to greater enrichment in all harvested tissues compared to lower doses (4 mg).

Conclusions:

  • Zinc methionine hydroxy analog chelate (Zn-MHAC) demonstrates superior bioavailability compared to inorganic zinc sulfate (Zn-SO) in ruminating calves.
  • Stable isotopes are effective tools for assessing zinc absorption and tissue distribution.
  • Dietary zinc dose significantly impacts zinc absorption and tissue enrichment.