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Related Concept Videos

Oogenesis02:07

Oogenesis

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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  1. Home
  3. Research Domains
  5. Biological Sciences
  7. Genetics
  9. Epigenetics (incl. Genome Methylation And Epigenomics)
  11. Epigenetics' Responsibility In Endometriosis: A Comprehensive Assessment

Epigenetics' Responsibility in Endometriosis: A comprehensive assessment

Oyedayo Phillips Akano1, Victor Oluwaloseyi Amos2, Israel Opeyemi Fawole3

  • 1Department of Physiology, Babcock University, Ilishan Remo, Ogun State, Nigeria.

The Journal of Steroid Biochemistry and Molecular Biology
|June 13, 2025

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Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis
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Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
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Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

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View abstract on PubMed

Summary
This summary is machine-generated.

Epigenetic modifications like DNA methylation and non-coding RNAs play a key role in endometriosis development. Targeting these reversible changes offers new hope for effective endometriosis treatments.

Area of Science:

  • Gynecology
  • Molecular Biology
  • Epigenetics

Background:

  • Endometriosis is a chronic inflammatory disease affecting women of reproductive age.
  • Its exact cause is unknown, but involves genetic, hormonal, and environmental factors.
  • Epigenetic processes are increasingly recognized as crucial in its development.

Purpose of the Study:

  • To explore the role of epigenetic alterations in endometriosis pathophysiology.
  • To highlight the potential of epigenetic modifications as therapeutic targets.

Main Methods:

  • Review of current research on epigenetic mechanisms in endometriosis.
  • Analysis of DNA methylation, histone modifications, and non-coding RNAs.

Main Results:

Keywords:
DNA MethylationEndometriosisEpigeneticsGene Expression

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  • Aberrant DNA methylation affects genes involved in immunity and estrogen metabolism, promoting lesion invasiveness.
  • Histone modifications alter gene expression by changing chromatin structure.
  • Non-coding RNAs, especially microRNAs, influence tissue remodeling and inflammation.

    • Conclusions:

    • Epigenetic modifications are integral to the abnormal behavior of ectopic endometrial cells.
    • The reversible nature of epigenetics presents promising therapeutic avenues.
    • Further research is needed to develop effective epigenetic-based endometriosis therapies.
    Histone Modification
    Non-Coding RNAs
    Pathophysiology
    Therapeutic Targets