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Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

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Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
943
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
686
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

1.8K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.8K
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

557
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
557

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Related Experiment Video

Updated: May 5, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
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Reversed Remodeling Unveils Mitral Annular Disjunction.

Tess Calcagno1, Joseph El Roumi1, Christopher Black1

  • 1Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

JACC. Case Reports
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Mitral annular disjunction (MAD) is often linked to cardiomyopathy. This case shows how cardiac MRI can reveal MAD in nonischemic cardiomyopathy (NICM) as the heart condition improves.

Area of Science:

  • Cardiology
  • Cardiac Imaging
  • Structural Heart Disease

Background:

  • Mitral annular disjunction (MAD) is a recognized abnormality associated with mitral valve prolapse (MVP) and cardiomyopathy.
Keywords:
arrhythmogenic mitral valve diseaseatrial fibrillationcardiac MRIcardiac imagingcardiac remodelingextracellular volume fraction (ECV)guideline-directed medical therapy (GDMT)heart failurelate gadolinium enhancement (LGE)left ventricular dysfunctionmitral annular disjunction (MAD)mitral regurgitationmitral valve prolapse (MVP)myocardial fibrosismyocardial scarnonischemic cardiomyopathy (NICM)reverse remodelingrisk stratificationsudden cardiac death (SCD)ventricular arrhythmia

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  • Its role in nonischemic cardiomyopathy (NICM) requires further elucidation.