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Updated: Apr 11, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
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4-Year Follow-Up After Transcatheter Aortic Valve Replacement With an Intraventricular Membranous Septal Aneurysm

Daisuke Sato1, Mikko Jalanko2, Tommi Vähäsilta3

  • 1Department of Cardiology, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland; Department of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan.

JACC. Case Reports
|June 13, 2025
PubMed

Insights

Transcatheter aortic valve replacement in patients with intraventricular membranous septal aneurysm is complex. Serial echocardiography showed no adverse cardiovascular events during follow-up, indicating a safe procedure.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Echocardiography

Background:

  • Transcatheter aortic valve replacement (TAVR) is a common procedure for aortic stenosis.
  • Intraventricular membranous septal aneurysms present unique challenges during TAVR.
  • Potential complications include thrombus formation and aneurysm expansion.

Purpose of the Study:

  • To evaluate the safety and outcomes of TAVR in patients with intraventricular membranous septal aneurysms.
  • To assess the changes in aneurysm size and thrombus formation post-TAVR using serial echocardiography.

Main Methods:

  • Retrospective analysis of serial echocardiographic images.
  • Patients undergoing TAVR with pre-existing intraventricular membranous septal aneurysms were included.
  • Echocardiograms were reviewed for aneurysm dimensions, thrombus presence, and overall cardiac function.

Main Results:

  • No instances of thrombus formation within the aneurysm were observed.
  • No significant expansion of the intraventricular membranous septal aneurysm was detected.
  • Patients experienced no adverse cardiovascular events during the follow-up period.

Conclusions:

  • TAVR can be performed safely in patients with intraventricular membranous septal aneurysms.
  • Serial echocardiography demonstrates stability of the aneurysm and absence of thrombus post-procedure.
  • This approach offers a viable treatment option for selected patients.

Keywords:
aortic stenosisintraventricular membranous septal aneurysmtranscatheter aortic valve replacement

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