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Updated: Jun 16, 2025
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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
18.2K
Orthobiologics: Injectable Treatments for Knee Osteoarthritis.
Angelo Boffa1, Giuseppe Filardo2
1Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Clinics in Sports Medicine
|June 13, 2025
Summary
Platelet-rich plasma (PRP) and cell-based therapies show promise for knee osteoarthritis. PRP has the most supporting data, while bone marrow and adipose-derived treatments offer options for specific patient groups.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Biotechnology
Background:
- Knee osteoarthritis (OA) is a significant clinical challenge.
- Autologous orthobiologic therapies are emerging as treatment options for knee OA.
- Platelet-rich plasma (PRP), bone marrow concentrates, and adipose-derived treatments are key injectable therapies.
Purpose of the Study:
- To review and compare autologous orthobiologic injectable therapies for knee osteoarthritis.
- To highlight the current evidence and clinical standing of PRP, bone marrow, and adipose-derived treatments.
Main Methods:
- Literature review of studies on intra-articular orthobiologic treatments for knee OA.
- Analysis of data supporting platelet-rich plasma (PRP).
- Evaluation of bone marrow concentrate and adipose-derived cell therapies.
Main Results:
- Platelet-rich plasma (PRP) demonstrates substantial supporting data and superiority in comparative trials.
- Bone marrow concentrates are frequently used for subchondral bone injections.
- Adipose-derived treatments show potential for advanced or less responsive OA cases.
Conclusions:
- PRP is currently the most supported orthobiologic injectable therapy for knee OA.
- Bone marrow and adipose-derived therapies offer valuable alternatives for specific OA patient populations.
- Further research will continue to refine the application of these regenerative treatments.
