Related Experiment Video
Updated: Jun 16, 2025

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Role of Umbilical Cord-Derived Mesenchymal Stem Cells and Derivatives for Treating Knee Osteoarthritis and Chondral
Ismail Hadisoebroto Dilogo1, Ludwig Andribert Powantia Pontoh2, Anissa Feby Canintika3
1Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta Pusat, DKI Jakarta, 10430, Indonesia; Stem Cell and Tissue Engineering Cluster, IMERI, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, DKI Jakarta, 10430, Indonesia; Stem Cell Medical Technology Installation, Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, 10430, Indonesia.
Abstract:
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are being investigated as a potential treatment of osteoarthritis (OA), the most prevalent degenerative joint disease worldwide. Conversely, concerns about its paracrine effect are drawing attention to noncellular alternatives such as secretomes and exosomes. The potential of hUC-MSCs, exosomes, and secretomes in cartilage regeneration is reported through a systematic evaluation of 44 publications, including investigations on humans and animals. Even with promising results, more research is necessary to eliminate bias and validate findings for use in clinical therapeutic settings.
Related Concept Videos
Mesenchymal Stem Cells
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

