Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.1K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piezoelectric scaffolds for bone regeneration: a systematic review of preclinical studies.

Frontiers in bioengineering and biotechnology·2026
Same author

Regulatory Frameworks and Clinical Development of Orthobiologics Across Asia and Europe.

The Journal of bone and joint surgery. American volume·2026
Same author

Orthobiologics at a Crossroads: From Biological Promise to Evidence-Based Orthopaedic Practice.

The Journal of bone and joint surgery. American volume·2026
Same author

Routine intraoperative infection testing in presumed aseptic hip and knee revision: a matched cohort retrospective study.

Archives of orthopaedic and trauma surgery·2026
Same author

Bibliometric analysis of enthesis research: a comprehensive review from 1999 to 2024.

International orthopaedics·2026
Same author

Are orthobiologics a plausible therapeutic option for patello-femoral pathology? A systematic review of clinical and radiological outcomes.

Frontiers in bioengineering and biotechnology·2026

Related Experiment Video

Updated: Jun 16, 2025

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.3K

Matrices Used for Cartilage Regeneration.

Alberto Bulgarelli1, Luca Ruosi1, Pietro Conte1

  • 1Department of Orthopedics and Traumatology, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan 20089, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan 20072, Italy.

Clinics in Sports Medicine
|June 13, 2025
PubMed
Summary

This review examines three osteochondral scaffolds for knee cartilage repair, finding that Autologous Matrix-Induced Chondrogenesis (AMIC) with a collagen scaffold offers sustained improvements over microfracture alone. Optimal outcomes depend on lesion characteristics and patient factors.

Keywords:
AMICAcellular scaffoldAgili-CMaioRegenOsteochondral lesions

More Related Videos

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.0K
Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
08:55

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

Published on: July 6, 2022

2.0K

Related Experiment Videos

Last Updated: Jun 16, 2025

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
08:58

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

14.3K
Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.0K
Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
08:55

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration

Published on: July 6, 2022

2.0K

Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Knee articular cartilage defects significantly impair quality of life, similar to severe osteoarthritis.
  • Current treatments face challenges in achieving durable cartilage repair.

Purpose of the Study:

  • To review and compare the efficacy of three leading osteochondral scaffold matrices for knee cartilage repair.
  • To evaluate clinical outcomes and identify factors influencing successful knee cartilage regeneration.

Main Methods:

  • Review of current surgical strategies for knee articular cartilage defects.
  • Focus on three prominent osteochondral scaffolds: AMIC with Chondro-Gide, MaioRegen, and Agili-C.
  • Analysis of clinical outcomes and efficacy data for each scaffold.

Main Results:

  • Autologous Matrix-Induced Chondrogenesis (AMIC) combined with a porcine-derived collagen scaffold demonstrates sustained long-term clinical improvements.
  • The AMIC technique shows superior outcomes compared to microfracture alone for knee cartilage repair.
  • Efficacy of scaffolds is influenced by specific lesion characteristics and patient demographics.

Conclusions:

  • Osteochondral scaffolds, particularly AMIC, represent a promising advancement in knee cartilage repair.
  • Patient and lesion-specific factors are critical for optimizing surgical outcomes in cartilage regeneration.
  • Further research into tailored approaches based on individual patient profiles is warranted.