Advancing the science of recruitment for Alzheimer's clinical trials: Challenges and opportunities

Despite recent advancements in Alzheimer's disease therapeutics and diagnostics, significant challenges remain in accelerating participant recruitment-particularly among diverse populations-and ensuring equitable access to clinical trials. This paper summarizes discussions and recommendations from the 2024 Roundtable on Advancing the Science of Recruitment for Inclusive Alzheimer's Disease Clinical Trials, hosted by the USC Clinical Trial Recruitment Lab (CTRL). Bringing together 40 leading experts from across the Alzheimer's clinical trial ecosystem in the U.S., including thought leaders from academia, industry, government and philanthropy, the Roundtable examined critical barriers to inclusivity and explored emerging recruitment approaches. Discussions highlighted the need for strategies that expand patient access, remove systemic barriers, and foster inclusivity in clinical research.