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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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Evolving role for eosinophils in cancer: from bench to bedside
S Grisaru-Tal1, E A Jacobsen2, A Munitz3
1Department of Clinical Microbiology and Immunology, Faculty of Health and Medical Sciences, Tel-Aviv University, Israel.
Trends in Cancer
|June 13, 2025
Summary
Eosinophils are key immune cells in tumors, with roles that can be pro- or anti-tumorigenic. Understanding eosinophil functions in the tumor microenvironment (TME) may reveal new cancer therapies.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Eosinophils are increasingly recognized for their complex roles within the tumor microenvironment (TME).
- Technological advances highlight eosinophil heterogeneity and context-dependent functions, influencing tumor progression.
- Eosinophilia is frequently observed post-treatment, particularly with immunotherapy, suggesting a potential therapeutic benefit.
Purpose of the Study:
- To review the multifaceted roles of eosinophils in the tumor microenvironment.
- To explore eosinophil recruitment, immune cell interactions, and therapeutic potential.
- To discuss methodologies for studying eosinophil activity in cancer.
Main Methods:
- Literature review of recent advancements in understanding eosinophils in cancer.
- Analysis of eosinophil-mediated cytotoxicity mechanisms.
- Examination of eosinophil interactions with other immune cells, such as T cells.
Main Results:
- Eosinophils exhibit dual roles, capable of promoting or inhibiting tumor growth.
- They mediate cytotoxicity through specific granule proteins and reactive oxygen species.
- Eosinophils contribute to antitumor immunity via interactions with other immune cells.
Conclusions:
- Eosinophils are critical players in the tumor microenvironment with significant therapeutic implications.
- Further understanding of eosinophil biology may lead to novel therapeutic strategies in precision oncology.
- Eosinophils could serve as valuable biomarkers for cancer treatment response.
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