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Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Impact Of Age On Frailty In Liver Cirrhosis: A Prospective Cohort Study.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Impact Of Age On Frailty In Liver Cirrhosis: A Prospective Cohort Study.

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Published on: July 24, 2013

Impact of age on frailty in liver cirrhosis: a prospective cohort study.

Omkolsoum Alhaddad¹, Maha Elsabaawy², Asmaa Abedelhai¹

¹Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebeen Elkoom, Menoufia, Egypt.

Clinical and Experimental Medicine

|June 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Frailty in liver cirrhosis significantly increases with age, with over 90% of patients aged 70+ being frail. Both advanced age and hepatic dysfunction independently predict frailty, underscoring the need for better vulnerability assessment in older adults.

Keywords:

Aging Child–Pugh score Frailty Liver cirrhosis

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Area of Science:

Geriatrics
Hepatology
Clinical Medicine

Background:

Frailty is an emerging predictor of adverse outcomes in liver cirrhosis.
The interplay between aging and liver disease severity in driving frailty is not well understood.

Purpose of the Study:

To evaluate the impact of age on the prevalence, severity, and predictors of frailty in patients with liver cirrhosis.

Main Methods:

Prospective observational study of 460 adults with liver cirrhosis.
Frailty assessed using the Clinical Frailty Scale (CFS); patients classified as frail (CFS > 4) or non-frail (CFS ≤ 4).
Multivariate and logistic regression analyses performed to identify independent predictors of frailty.

Main Results:

Frailty prevalence increased markedly with age, from 42% in patients aged 50-59 to over 90% in those aged ≥ 70.

Age (β = 0.0636, p < 0.001) and Child-Pugh score (β = 0.7874, p < 0.001) were independent predictors of frailty.

Each additional year of age increased frailty risk (OR = 1.13; 95% CI: 1.09-1.17, p < 0.001).

Conclusions:

Frailty in cirrhosis is strongly age-associated and driven by hepatic dysfunction.
Current MELD-Na scores may inadequately capture patient vulnerability, especially in older adults.
Longitudinal studies and prehabilitation strategies are needed to mitigate frailty and improve outcomes.