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  11. Development, Characterization, And Molecular Dynamics Simulation Of Andrographolide Nanosuspensions Utilizing Hummer Acoustic Resonance Technology.
  1. Home
  3. Research Domains
  5. Chemical Sciences
  7. Medicinal And Biomolecular Chemistry
  9. Biologically Active Molecules
  11. Development, Characterization, And Molecular Dynamics Simulation Of Andrographolide Nanosuspensions Utilizing Hummer Acoustic Resonance Technology.

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Development, Characterization, and Molecular Dynamics Simulation of Andrographolide Nanosuspensions Utilizing Hummer Acoustic Resonance Technology.

Li Wang1, Xiaoyang Zhang1, Jianlu Qu1

  • 1College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

AAPS Pharmscitech
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Andrographolide nanosuspension (AG-NS) was rapidly developed using Hummer Acoustic Resonance (HAR) technology to overcome poor solubility. The optimized AG-NS showed enhanced dissolution and excellent redispersibility, improving therapeutic potential.

Keywords:
AndrographolideHummer acoustic resonanceMolecular dynamics simulationsNanosuspension

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Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Drug Delivery

Background:

  • Andrographolide (AG) possesses significant anti-inflammatory and immunomodulatory properties.
  • Poor water solubility of AG limits its clinical applications.
  • Development of effective drug delivery systems is crucial for AG's therapeutic utility.

Purpose of the Study:

  • To rapidly develop and optimize an andrographolide nanosuspension (AG-NS) using Hummer Acoustic Resonance (HAR) technology.
  • To enhance the solubility and dissolution rate of andrographolide.
  • To evaluate the physicochemical properties and redispersibility of the developed nanosuspension.

Main Methods:

  • Nanosuspension preparation utilizing HAR technology for high-throughput stabilizer screening.
Quality by design
  • Quality risk assessment and Box-Behnken design (BBD) for formulation optimization.
  • Physicochemical characterization, including particle size, polydispersity index (PDI), zeta potential, and redispersibility after lyophilization.
  • In vitro dissolution studies and molecular dynamics (MD) simulations.

    • Main Results:

    • Optimized AG-NS achieved a Z-average of 183.96 nm, PDI of 0.151, and zeta potential of -42.85 mV.
    • Lyophilized AG-NS demonstrated excellent redispersibility.
    • In vitro dissolution studies showed significantly faster dissolution rates and higher cumulative dissolution for AG-NS compared to crude AG and physical mixture.
    • MD simulations elucidated the stabilization mechanisms within the nanosuspension.

    Conclusions:

    • Hummer Acoustic Resonance (HAR) technology enables rapid and efficient development of nanosuspensions.
    • The optimized andrographolide nanosuspension (AG-NS) exhibits improved physicochemical properties and enhanced dissolution performance.
    • This nanosuspension formulation holds promise for overcoming the solubility limitations of andrographolide, potentially improving its therapeutic efficacy.