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[Isolation of Actinomycetales from the soil of Kazakhstan on selective media with antibiotics].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]·1990

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology·1986

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[Some propeties of roseofungin].

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[ON THE NATURE OF THE CHROMOFOROUS GROUP OF COELICOMYCIN].

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Related Experiment Video

Updated: Jul 4, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

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[Identification with roseofungin of an antibiotic produced by Streptomyces roseoflavus strain A-23/791 and its

A S Daurenbekova, L A Vetlugina

Antibiotiki I Meditsinskaia Biotekhnologiia = Antibiotics and Medical Biotechnology

|July 1, 1985

Summary

A novel antibiotic from Streptomyces roseoflavus effectively combats plant fungal diseases and promotes plant growth. An improved isolation method from a variant strain yields a more potent and active antibiotic, identified as roseofungin.

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Area of Science:

Microbiology
Mycology
Biochemistry

Background:

Streptomyces roseoflavus produces bioactive compounds.
Phytopathogenic fungi cause significant crop losses.
Plant growth-promoting substances are valuable in agriculture.

Purpose of the Study:

To isolate, purify, and identify an antibiotic from Streptomyces roseoflavus.
To evaluate the antibiotic's efficacy against plant pathogens and its growth-promoting effects.
To compare the productivity of the original strain and its adifferentiated variant.

Main Methods:

Isolation and purification of the antibiotic.
Chemical identification using spectroscopic methods (UV, IR, mass) and chromatography.
Bioassays for antifungal activity and plant growth promotion.
Hydroponic cultivation for root rot control experiments.

Main Results:

The antibiotic inhibits phytopathogenic fungi, dermatophytes, and yeast-like fungi.
The adifferentiated variant (4-76) is more productive and yields a more active antibiotic.
The antibiotic effectively controls cucumber root rot in hydroponics.
Chemical analysis confirmed the antibiotic is identical to roseofungin.

Conclusions:

The isolated antibiotic, roseofungin, possesses significant antifungal and plant growth-promoting properties.
The adifferentiated variant and a simplified isolation method enhance antibiotic production and yield.
Strain IMV A-23/791 should be classified as Streptomyces roseoflavus var. roseofungini.